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BACH2 Protein, Human (sf9)

BACH2 is a multifunctional transcriptional regulator that acts as both a repressor and an activator and recognizes Maf recognition elements (MAREs) to coordinate the transcriptional regulation of MAFKs. During oxidative stress, BACH2 induces apoptosis by inhibiting HMOX1. BACH2 Protein, Human (sf9) is the recombinant human-derived BACH2 protein, expressed by sf9 insect cells , with tag free.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: Sf9 insect cells
  • BACH2 Protein, Human (sf9) Product Image
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609-228-6898
[email protected] [email protected]
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Biological Activity

Description

BACH2 is a multifunctional transcriptional regulator that acts as both a repressor and an activator and recognizes Maf recognition elements (MAREs) to coordinate the transcriptional regulation of MAFKs. During oxidative stress, BACH2 induces apoptosis by inhibiting HMOX1. BACH2 Protein, Human (sf9) is the recombinant human-derived BACH2 protein, expressed by sf9 insect cells , with tag free.

Background

BACH2, a versatile transcriptional regulator, exhibits dual roles as a repressor and activator. Recognizing Maf recognition elements (MARE), it coordinates transcriptional activation and repression in conjunction with MAFK. In response to oxidative stress, BACH2 induces apoptosis by repressing the antiapoptotic factor HMOX1. Moreover, it plays a pivotal role in adaptive immunity, critically contributing to the maintenance of regulatory T-cell function and B-cell maturation. BACH2 forms homodimers, disulfide-linked, and heterodimers with Maf-related transcription factors, emphasizing its involvement in complex regulatory networks. Additionally, BACH2 serves as a positive regulator of the nuclear import of actin, underscoring its diverse functions in cellular processes.

Technical Parameters

  • Species Human
  • Source Sf9 insect cells
  • Tag Tag Free
  • Accession

    Q9BYV9 (S2-T841)

  • Gene ID
    60468
  • Molecular Construction
    • N-term
    • BACH2 (S2-T841)
      Accession # Q9BYV9
    • C-term
  • Protein Length

    Partial

  • Synonyms

    BACH2; BTB And CNC Homology 1, Basic Leucine Zipper Transcription Factor 2; BACH Transcriptional Regulator 2; BTB Domain And CNC Homolog 2; Transcription Regulator Protein BACH2; BTB And CNC Homolog 2; BTBD25; IMD60

  • AA Sequence

    SVDEKPDSPMYVYESTVHCTNILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKNDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNSEDGLFVCRKDAACQRPHEDCENSAGEEEDEEEETMDSETAKMACPRDQMLPEPISFEAAAIPVAEKEEALLPEPDVPTDTKESSEKDALTQYPRYKKYQLACTKNVYNASSHSTSGFASTFREDNSSNSLKPGLARGQIKSEPPSEENEEESITLCLSGDEPDAKDRAGDVEMDRKQPSPAPTPTAPAGAACLERSRSVASPSCLRSLFSITKSVELSGLPSTSQQHFARSPACPFDKGITQGDLKTDYTPFTGNYGQPHVGQKEVSNFTMGSPLRGPGLEALCKQEGELDRRSVIFSSSACDQVSTSVHSYSGVSSLDKDLSEPVPKGLWVGAGQSLPSSQAYSHGGLMADHLPGRMRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNQLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLRPMDLPTASSINPAPLGAEQNIAASQCAVGENVPCCLEPGAAPPGPPWAPSNTSENCTSGRRLEGTDPGTFSERGPPLEPRSQTVTVDFCQEMTDKCTTDEQPRKDYT

  • Purity

    ≥ 85%, as determined by reducing SDS-PAGE.

Calculators

Reconstitution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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