2. Recombinant Proteins
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. N-Cadherin
  7. Cadherin-12/CDH12 Protein, Human (HEK293, His)

Cadherin-12/CDH12 Protein, Human (HEK293, His)

Cat. No.: HY-P75667
Handling Instructions

Cadherin-12/CDH12 is a calcium-dependent cell adhesion protein in the cadherin family known for its preferential homophilic interactions (binding to itself between connecting cells). This interaction is shown to play a crucial role in mediating cell adhesion and may play a key role in sorting heterogeneous cell types. Cadherin-12/CDH12 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-12/CDH12 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-12/CDH12 Protein, Human (HEK293, His) is 582 a.a., with molecular weight of 80-85 kDa.

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Description

Cadherin-12/CDH12 is a calcium-dependent cell adhesion protein in the cadherin family known for its preferential homophilic interactions (binding to itself between connecting cells). This interaction is shown to play a crucial role in mediating cell adhesion and may play a key role in sorting heterogeneous cell types. Cadherin-12/CDH12 Protein, Human (HEK293, His) is the recombinant human-derived Cadherin-12/CDH12 protein, expressed by HEK293 , with C-His labeled tag. The total length of Cadherin-12/CDH12 Protein, Human (HEK293, His) is 582 a.a., with molecular weight of 80-85 kDa.
Background

Cadherin-12/CDH12 protein, belonging to the cadherin family, operates as a calcium-dependent cell adhesion protein. Known for its preferential homophilic interaction, Cadherin-12/CDH12 engages in binding with itself between connecting cells. This homophilic cadherin interaction implies a significant role in mediating cell adhesion and may play a crucial part in the intricate process of sorting heterogeneous cell types. Through its calcium-dependent adhesive properties, Cadherin-12/CDH12 likely contributes to the establishment of selective connections between cells, thereby participating in the dynamic regulation of cellular interactions and tissue organization.
Species

Human
Source

HEK293
Tag

C-His
Accession

P55289-1/NP_001304156.1 (Q24-A605)
Gene ID

1010
Molecular Construction
N-term
CDH12 (Q24-A605)
Accession # P55289
His
C-term
Synonyms
CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB; Br-cadherin; N-cadherin 2; brain cadherin; brain-cadherin; neuronal cadherin 2; neural type cadherin 2; cadherin, neural type, 2; FLJ34857;
Molecular Weight

80-85 kDa
Purity

Greater than 80% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Cadherin-12/CDH12 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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