Cadherin-8 Protein, Human (HEK293, His)

Cadherin-8 Protein, Human (HEK293, His), a recombinant human Cadherin-8 produced in HEK293 cells, has a His tag at the N-terminus. Cadherin-8 (Cdh8) is a classical type II cadherin that can bind β-catenin and has a role in the migration and growth of other neuronal cell types^[1].

Cadherin-8 (Cdh8) is a classical type II cadherin that can bind β-catenin. Most studies examined Cdh8 expression perinatally and postnatally, when it is expressed strongly in certain layers of the cortex, hippocampus and striatum. Cdh8 has also been found to have a role in the migration and growth of other neuronal cell types^[1].

Human

HEK293

C-6*His

P55286 (A30-M621)

1006  [NCBI]

APMNQSQVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMHHHHHH

Approximately 89.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Fani Memi, et al. Cadherin 8 regulates proliferation of cortical interneuron progenitors. Brain Struct Funct. 2019 Jan;224(1):277-292.  [Content Brief]