1. Recombinant Proteins
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. Cell Adhesion Molecule 3 (CADM3)
  6. CADM3 Protein, Rat (HEK293, His)

CADM3 Protein, Rat (HEK293, His)

Cat. No.: HY-P76758
Handling Instructions

CADM3 protein is a multifunctional cell adhesion molecule that participates in calcium-independent homophilic and heterophilic intercellular adhesion together with IGSF4, NECTIN1, and NECTIN3. Its interaction with EPB41L1 regulates cell-cell connections. CADM3 Protein, Rat (HEK293, His) is the recombinant rat-derived CADM3 protein, expressed by HEK293 , with C-His labeled tag. The total length of CADM3 Protein, Rat (HEK293, His) is 328 a.a., with molecular weight of 35-40 kDa.

For research use only. We do not sell to patients.

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Description

CADM3 protein is a multifunctional cell adhesion molecule that participates in calcium-independent homophilic and heterophilic intercellular adhesion together with IGSF4, NECTIN1, and NECTIN3. Its interaction with EPB41L1 regulates cell-cell connections. CADM3 Protein, Rat (HEK293, His) is the recombinant rat-derived CADM3 protein, expressed by HEK293 , with C-His labeled tag. The total length of CADM3 Protein, Rat (HEK293, His) is 328 a.a., with molecular weight of 35-40 kDa.

Background

CADM3, a cell adhesion molecule, intricately participates in cell-cell adhesion processes. It exhibits both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1, and NECTIN3, emphasizing its versatility in mediating diverse cell interactions. Furthermore, CADM3's interaction with EPB41L1 suggests a potential role in regulating the structure or function of cell-cell junctions. The protein forms homodimers and has the capacity to create trans-heterodimers with NECTIN3, highlighting its ability to engage in various adhesive interactions. Additionally, CADM3 interacts with EPB41L1, DLG3, PALS2, and CASK, further underscoring its involvement in intricate cellular signaling and junction dynamics. The multifaceted nature of CADM3 positions it as a key player in cell adhesion and intercellular communication.

Species

Rat

Source

HEK293

Tag

C-His

Accession

Q1WIM3 (M1-H328)

Gene ID

360882  [NCBI]

Molecular Construction
N-term
CADM3 (M1-H328)
Accession # Q1WIM3
His
C-term
Synonyms
Cell adhesion molecule 3; IgSF4B; NECL-1; Syncam3
Molecular Weight

35-40 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CADM3 Protein, Rat (HEK293, His)
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HY-P76758
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