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  5. CD34 Protein, Rat (HEK293, Fc)

CD34 Protein, Rat (HEK293, Fc)

Cat. No.: HY-P74304
Handling Instructions

CD34 Protein is a transmembrane phosphoglycoprotein that exists on the surface of human and various animal cells. CD34 Protein is used as a cellular marker for hematopoietic stem cell sorting and as an islet endocrine cell marker. CD34 Protein plays an important role in cell adhesion, inflammatory cell chemotaxis, cell proliferation and differentiation, and enhancement of inflammatory response. CD34 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD34 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD34 Protein, Rat (HEK293, Fc) is 255 a.a., with molecular weight of 95-130 kDa.

For research use only. We do not sell to patients.

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Description

CD34 Protein is a transmembrane phosphoglycoprotein that exists on the surface of human and various animal cells. CD34 Protein is used as a cellular marker for hematopoietic stem cell sorting and as an islet endocrine cell marker. CD34 Protein plays an important role in cell adhesion, inflammatory cell chemotaxis, cell proliferation and differentiation, and enhancement of inflammatory response. CD34 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD34 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD34 Protein, Rat (HEK293, Fc) is 255 a.a., with molecular weight of 95-130 kDa.

Background

CD34 is a transmembrane phosphoglycoprotein present on the surface of human and various animal cells, and it was first described in hematopoietic stem cells as an intercellular adhesion factor. CD34 is used as a cellular marker for hematopoietic stem cell sorting and as an islet endocrine cell marker. CD34 can mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells. CD34 may also play a more selective role in the chemokine-dependent migration of eosinophils and dendritic cell precursors. CD34 plays an important role in cell adhesion, inflammatory cell chemotaxis, cell proliferation and differentiation, and enhancement of inflammatory response[1][2][3][4].

Species

Rat

Source

HEK293

Tag

C-hFc

Accession

B1PLB1 (E37-T291)

Gene ID

305081  [NCBI]

Molecular Construction
N-term
CD34 (M1-T291)
Accession # B1PLB1
hFc
C-term
Synonyms
Hematopoietic progenitor cell antigen CD34; CD34; HPCA1
AA Sequence

ENSTQGVFPPVPTNESTEESITSSIPGSTSHYYLIGQDSNKTTPAISETTVNFTATPGTPSGSGTPHTFSQPQTYPTVTLPTTSDSTSTPEVEHSTWNTSLPSVNVSDYSPNNVSSEMISTTEPCAHTSSSVPSIIKGDIKCSGIRGVPFTQGICLELSEASSCEEFKKERGEELMQILCKKEETEADAGTSVCSLNLAQSEVRPECLLMVLANSTELSSKLQLMEKHQSDLRKLGIQSFNKQDLGSHQSYSRKT

Molecular Weight

Approximately 112 kDa due to the glycosylation.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CD34 Protein, Rat (HEK293, Fc)
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HY-P74304
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