CD44 Protein, Human (242a.a, HEK293, hFc)
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (242a.a, HEK293, hFc) is a recombinant protein dimer complex containing human-derived CD44 protein, expressed by HEK293 , with C-hFc labeled tag. CD44 Protein, Human (242a.a, HEK293, hFc), has molecular weight of 70-100 kDa.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (242a.a, HEK293, hFc) is a recombinant protein dimer complex containing human-derived CD44 protein, expressed by HEK293 , with C-hFc labeled tag. CD44 Protein, Human (242a.a, HEK293, hFc), has molecular weight of 70-100 kDa.
Background
CD44, a cell-surface receptor, plays a pivotal role in cell-cell interactions, adhesion, and migration, enabling cells to sense and respond to alterations in the tissue microenvironment. Its involvement extends to diverse cellular functions, including the activation, recirculation, and homing of T-lymphocytes, hematopoiesis, inflammation, and response to bacterial infection. CD44 engages various extracellular matrix components, such as hyaluronan/HA, collagen, growth factors, cytokines, or proteases through its ectodomain, serving as a platform for signal transduction. This involves the assembly of protein complexes via its cytoplasmic domain, containing receptor kinases and membrane proteases. Effectors like PKN2, RAC1, RHOA, Rho-kinases, and phospholipase C coordinate signaling pathways with CD44, leading to calcium mobilization and actin-mediated cytoskeleton reorganization, crucial for cell migration and adhesion. CD44 interacts with a spectrum of molecules, including PKN2, TIAM1, TIAM2, hyaluronan, collagen, laminin, fibronectin, UNC119, PDPN, RDX, EZR, MSN, EGFR, and CD74, forming a complex network essential for its diverse cellular functions.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
P16070-1 (Q21-P220 & Q386-A427)
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Gene ID960
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Protein Length
Partial Extracellular Domain
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Synonyms
CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
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Predicted Molecular Mass
53.6 kDa
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Molecular Weight
Approximately 70-100 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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