CD64 Protein, Cynomolgus (HEK293, His)
The CD64 protein is a high-affinity receptor for the immunoglobulin gamma Fc region and plays a key role in innate and adaptive immune responses. It prevents FCGR1A degradation by interacting with FCERG1 and FLNA to form a functional signaling complex. CD64, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD64 protein, expressed by HEK293, with C-mFc labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CD64 protein is a high-affinity receptor for the immunoglobulin gamma Fc region and plays a key role in innate and adaptive immune responses. It prevents FCGR1A degradation by interacting with FCERG1 and FLNA to form a functional signaling complex. CD64, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD64 protein, expressed by HEK293, with C-mFc labeled tag.
Background
CD64 Protein emerges as a high-affinity receptor specifically designed for the Fc region of immunoglobulins gamma, playing a pivotal role in both innate and adaptive immune responses. Its dynamic functionality extends to forming a functional signaling complex through interaction with FCERG1. Additionally, CD64 interacts with FLNA, preventing FCGR1A degradation, and engages with EPB41L2, LAT, and PPL in intricate cellular processes. Furthermore, this receptor establishes connections with HCK and LYN, showcasing its versatility and involvement in various signaling cascades critical for immune system modulation.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-His
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Accession
NP_001270969.1 (V11-P288)
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Gene ID102147198
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Protein Length
Partial
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Synonyms
FCGR1A; Fc Fragment Of IgG Receptor Ia; Fc Gamma Receptor Ia; IgG Fc Receptor I; FcgammaRIa; Fc-Gamma RIA; FCGR1; Fc-Gamma RI; FCG1; IGFR1; FcgammaRI; Fc-Gamma Receptor I A1; CD64A; CD64 Antigen; CD64; Fc Gamma RI; Fc Fragment Of IgG, High Affinity Ia, Receptor For (CD64); FCRI; Fc Fragment Of IgG, High Affinity Ia, Receptor (CD64); FcRI; High Affinity Immunoglobulin Gamma Fc Receptor I
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AA Sequence
VPVDGQVDTTKAVITLQPPWVSVFQEETVTLQCEVPRLPGSSSTQWFLNGTATQTSTPSYRITSASVKDSGEYRCQRGPSGRSDPIQLEIHRDWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYQNGKAFKFFYRNSQLTILKTNISHNGAYHCSGMGKHRYTSAGVSVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGFYWCEATTEDGNVLKRSPELELQVLGLQLPTP
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Predicted Molecular Mass
33.2 kDa
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Molecular Weight
Approximately 40-50 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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