CDCP1 Protein, Human (339a.a, HEK293, His)
CDCP1 protein may be involved in cell adhesion and extracellular matrix association. Phosphorylation of CDCP1 may regulate the balance between anchorage and migration, proliferation, and differentiation. CDCP1 Protein, Human (339a.a, HEK293, His) is the recombinant human-derived CDCP1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
CDCP1 protein may be involved in cell adhesion and extracellular matrix association. Phosphorylation of CDCP1 may regulate the balance between anchorage and migration, proliferation, and differentiation. CDCP1 Protein, Human (339a.a, HEK293, His) is the recombinant human-derived CDCP1 protein, expressed by HEK293 , with C-His labeled tag.
Background
CDCP1 protein is potentially involved in cell adhesion and the association with the extracellular matrix. Its phosphorylation may play a role in regulating the balance between anchorage and migration, as well as proliferation and differentiation. Additionally, CDCP1 has shown promise as a novel marker for leukemia diagnosis and for identifying immature hematopoietic stem cell subsets. It belongs to the tetraspanin web, which is implicated in tumor progression and metastasis. CDCP1 interacts with several proteins including CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4, the serine protease ST14/MT-SP1, as well as SRC and PRKCG/protein kinase C gamma, suggesting its involvement in various cellular processes and signaling pathways.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-8*His
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Accession
Q9H5V8-1 (F30-R368)
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Molecular Construction
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N-term
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CDCP1 (F30-R368)
Accession # Q9H5V8-1 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CDCP1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; CUB Domain Containing Protein 1; Transmembrane And Associated With Src Kinases; SIMA135; Membrane Glycoprotein Gp140; CUB Domain-Containing Protein 1; TRASK; CD318; CD318 Antigen
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AA Sequence
FEIALPRESNITVLIKLGTPTLLAKPCYIVISKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIEPRPVKQSR
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Predicted Molecular Mass
39 kDa
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Molecular Weight
Approximately 60-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
References
[1]. Qi X, et al. CDCP1: A promising diagnostic biomarker and therapeutic target for human cancer. Life Sci. 2022 Jul 15;301:120600. [Content Brief]
[2]. He Y, et al. CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene. 2020 Jan;39(1):219-233. [Content Brief]
[3]. Kajiwara K, et al. CDCP1 promotes compensatory renal growth by integrating Src and Met signaling. Life Sci Alliance. 2021 Feb 11;4(4):e202000832. [Content Brief]
[4]. Conze T, et al. CDCP1 is a novel marker for hematopoietic stem cells. Ann N Y Acad Sci. 2003 May;996:222-6. [Content Brief]
[5]. Scherl-Mostageer M, et al. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene. 2001 Jul 19;20(32):4402-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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