2. Recombinant Proteins
  3. Enzymes & Regulators Kinases
  4. Transferases (EC 2) Serine/Threonine Kinase Proteins CMGC
  5. Cyclin-Dependent Kinases (CDKs) CDK
  6. CDK13/CHED
  7. CDK13 Protein, Human (sf9, GST)

CDK13 Protein, Human (sf9, GST) is the recombinant human-derived CDK13, expressed by sf9 insect cells , with GST labeled tag.

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100 μg   견적 받기  

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제품 설명

CDK13 Protein, Human (sf9, GST) is the recombinant human-derived CDK13, expressed by sf9 insect cells , with GST labeled tag.
Background

CDK13-CCNT1 is a cyclin-dependent kinase with CTD kinase activity, essential for RNA splicing. It hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, acting as a key regulator of transcription elongation. It likely participates in RNA splicing by phosphorylating SRSF1/SF2 and plays a role during hematopoiesis. During HIV-1 infection, CDK13-CCNT1 interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', enhancing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Species

Human
Source

Sf9 insect cells
Tag

GST
Accession

Q14004-1 (Q673-S1054)
Gene ID

8621
Protein Length

Partial
Synonyms
CDC2L; CDC2L5; CHED; KIAA1791
AA Sequence

QLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDS

Predicted Molecular Mass
71 kDa
Purity

≥ 80%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
각종 서류
Handling Instructions (2659 KB)

CDK13 Protein, Human (sf9, GST) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CDK13 Protein, Human (sf9, GST)
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HY-P703598
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