CHN1 Protein, Human (sf9, His-GST)
CHN1 protein, a GTPase-activating protein for p21-rac, acts as a phorbol ester receptor and is crucial in assembling neuronal locomotor circuits. It serves as a direct effector of EPHA4, linking EPHA4 activation to RAC1 regulation. CHN1's interaction with EPHA4 influences axon guidance signaling pathways, impacting the development and organization of essential neuronal circuits for proper locomotion. CHN1 Protein, Human (sf9, His-GST) is the recombinant human-derived CHN1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CHN1 protein, a GTPase-activating protein for p21-rac, acts as a phorbol ester receptor and is crucial in assembling neuronal locomotor circuits. It serves as a direct effector of EPHA4, linking EPHA4 activation to RAC1 regulation. CHN1's interaction with EPHA4 influences axon guidance signaling pathways, impacting the development and organization of essential neuronal circuits for proper locomotion. CHN1 Protein, Human (sf9, His-GST) is the recombinant human-derived CHN1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
Background
CHN1, a GTPase-activating protein for p21-rac, serves as a phorbol ester receptor and plays a pivotal role in the assembly of neuronal locomotor circuits. It functions as a direct effector of EPHA4 in axon guidance, forming a critical link between EPHA4 activation and the regulation of RAC1. Through its interaction with EPHA4, CHN1 contributes to the intricate signaling pathways involved in axon guidance, thereby influencing the development and organization of neuronal circuits essential for proper locomotion.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-His;N-GST
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Accession
P15882 (A2-F459)
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Molecular Construction
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N-term
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His-GST
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CHN1 (A2-F459)
Accession # P15882 -
C-term
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Protein Length
Full Length
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Synonyms
CHN1; Chimerin (Chimaerin) 1; Prev. CHN; NC; Prev. DURS2; Chimerin 1 (GTPase-Activating Protein, Rho, 2); N-Chimerin; Rho GTPase-Activating Protein 3; ARHGAP2; Duane Retraction Syndrome 2; Rho GTPase-Activating Protein 2; Alternative Protein CHN1; Alpha-C
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AA Sequence
ALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF
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Predicted Molecular Mass
80.9 kDa
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Molecular Weight
Approximately 65 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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