CHN1 Protein, Human (sf9, His-GST)

CHN1 protein, a GTPase-activating protein for p21-rac, acts as a phorbol ester receptor and is crucial in assembling neuronal locomotor circuits. It serves as a direct effector of EPHA4, linking EPHA4 activation to RAC1 regulation. CHN1's interaction with EPHA4 influences axon guidance signaling pathways, impacting the development and organization of essential neuronal circuits for proper locomotion. CHN1 Protein, Human (sf9, His-GST) is the recombinant human-derived CHN1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

CHN1, a GTPase-activating protein for p21-rac, serves as a phorbol ester receptor and plays a pivotal role in the assembly of neuronal locomotor circuits. It functions as a direct effector of EPHA4 in axon guidance, forming a critical link between EPHA4 activation and the regulation of RAC1. Through its interaction with EPHA4, CHN1 contributes to the intricate signaling pathways involved in axon guidance, thereby influencing the development and organization of neuronal circuits essential for proper locomotion.

Human

Sf9 insect cells

N-His;N-GST

P15882 (A2-F459)

1123  [NCBI]

Full Length of Mature Protein

ALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVSEKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF

Approximately 65 kDa,based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.