2. Recombinant Proteins
  3. Receptor Proteins
  4. Pattern Recognition Receptors
  5. C-type Lectin Receptors
  6. Macrophage-inducible C-type Lectin/CLEC4E
  7. CLEC4E Protein, Rhesus Macaque (HEK293, Fc)

CLEC4E Protein, Rhesus Macaque (HEK293, Fc)

Cat. No.: HY-P77336
COA Handling Instructions

CLEC4E Protein is a calcium-dependent lectin displaying mannose-binding specificity, and induces the formation of Birbeck granules (BGs). CLEC4E Protein is a potent regulator of membrane superimposition and zippering, and binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC4E protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is 179 a.a., with molecular weight of ~49.1 KDa.

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Description

CLEC4E Protein is a calcium-dependent lectin displaying mannose-binding specificity, and induces the formation of Birbeck granules (BGs). CLEC4E Protein is a potent regulator of membrane superimposition and zippering, and binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC4E protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is 179 a.a., with molecular weight of ~49.1 KDa.
Background

CLEC4E Protein facilitates uptake of antigens and is involved in the routing or processing of antigen for presentation to T cells. C-type lectin domain family 4 member E is a major receptor on primary langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. C-type lectin domain family 4 member E protects against human immunodeficiency virus-1 (HIV-1) infection[1][2][3][4].
Species

Rhesus Macaque
Source

HEK293
Tag

N-hFc
Accession

XP_001118423 (R41-I219)
Gene ID

722250  [NCBI]
Molecular Construction
N-term
hFc
CLEC4E (R41-I219)
Accession # XP_001118423
C-term
Synonyms
C-Type Lectin Domain Family 4 Member E; CLECSF9; MINCLE
Molecular Weight

Approximately 49.1 kDa.
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation

COA (220 KB)

Handling Instructions (2659 KB)

CLEC4E Protein, Rhesus Macaque (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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