Eotaxin/CCL11 Protein, Human (His)
Eotaxin/CCL11 Protein actively promotes eosinophil accumulation in response to allergens, a distinctive feature of allergic inflammation, emphasizing its pivotal role in immune response orchestration during allergies. This regulatory function is achieved through binding to the CCR3 receptor, underscoring its specific interaction with cellular receptors to modulate eosinophil migration and activation in response to allergenic stimuli. Eotaxin/CCL11 Protein, Human (His) is the recombinant human-derived Eotaxin/CCL11 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Eotaxin/CCL11 Protein actively promotes eosinophil accumulation in response to allergens, a distinctive feature of allergic inflammation, emphasizing its pivotal role in immune response orchestration during allergies. This regulatory function is achieved through binding to the CCR3 receptor, underscoring its specific interaction with cellular receptors to modulate eosinophil migration and activation in response to allergenic stimuli. Eotaxin/CCL11 Protein, Human (His) is the recombinant human-derived Eotaxin/CCL11 protein, expressed by E. coli , with N-His labeled tag.
Background
In response to the presence of allergens, the Eotaxin/CCL11 protein actively facilitates the accumulation of eosinophils, a distinctive hallmark of allergic inflammatory reactions. This effect is well-documented in scientific literature, underscoring the protein's pivotal role in orchestrating immune responses during allergic processes. Notably, Eotaxin/CCL11 achieves this regulatory function by binding to the CCR3 receptor, highlighting its specific interaction with cellular receptors to modulate the migration and activation of eosinophils in response to allergenic stimuli.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-8*His
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Accession
P51671 (G24-P97)
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Molecular Construction
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N-term
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8*His
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CCL11 (G24-P97)
Accession # P51671 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
CCL11; Eosinophil Chemotactic Protein; Prev. SCYA11; MGC22554; Eotaxin; Small-Inducible Cytokine A11; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin); C-C Motif Chemokine 11; Chemokine (C-C Motif) Ligand 11; C-C Motif Chemokine; C-C Mo
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AA Sequence
GPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP
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Predicted Molecular Mass
9.5 kDa
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Molecular Weight
Approximately 13-15 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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