1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokines
  5. Eotaxin/CCL11
  6. Eotaxin/CCL11 Protein, Human

Eotaxin/CCL11 Protein, Human

Cat. No.: HY-P7159
COA Handling Instructions

Eotaxin/CCL11 Protein, Human is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.

For research use only. We do not sell to patients.

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Size Price Stock Quantity
10 μg $160 In-stock
50 μg $360 In-stock
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250 μg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

  • References


Eotaxin/CCL11 Protein, Human is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.


CCL11 is a small cytokine belonging to the CC chemokine family. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergicresponses[1]. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. CCL11 is a potent chemoattractant for eosinophils, basophils, and Th2 lymphocytes. CCL11 has a number of important biological functions in disease processes. It plays a critical role in allergic and nonallergic inflammatory reactions, such as mycobacterial and schistosomal induced granulomatosis[2].

In Vitro

CCL11 (0.1-100 nM, 48 h) can induce HMEC chemotaxis in a dose-dependent manner and can be blocked by 20 μg/mL of CCL11 mAb. However, CCL11 does not induce HMEC proliferation in vitro[3].
CCL11 (1-100 ng) can induce angiogenesis, with 78% at 100 ng and 63% at 10 ng but no significant angiogenic response was obtained at a dose of 1 ng in the chick CAM assay[3].

Biological Activity

Full biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration range of 0.1-10.0 ng/ml.




E. coli


Tag Free


P51671 (G24-P97)

Gene ID
rHuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11
AA Sequence


Molecular Weight

Approximately 8.4 kDa


Greater than 95% as determined by reducing SDS-PAGE.


Lyophilized powder.


Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl.

Endotoxin Level

<1 EU/μg, determined by LAL method.


It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.


Room temperature in continental US; may vary elsewhere.


Eotaxin/CCL11 Protein, Human Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Eotaxin/CCL11 Protein, Human
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