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FABP4 Protein, Mouse (His)

Cat. No.: HY-P75215
COA Handling Instructions

The FABP4 protein binds hormone receptors, fatty acids, and transports them. It regulates thermogenesis, brown fat cell differentiation, and response to lithium ion. It is located in the cytoplasm and nucleus, and is expressed in adipose tissue, CNS, genitourinary system, gut, and heart. It shares orthology with human FABP4. Biased expression is seen in subcutaneous and genital fat pads. FABP4 Protein, Mouse (His) is the recombinant mouse-derived FABP4 protein, expressed by E. coli , with N-His labeled tag. The total length of FABP4 Protein, Mouse (His) is 131 a.a., with molecular weight of ~15.63 kDa.

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Description

The FABP4 protein binds hormone receptors, fatty acids, and transports them. It regulates thermogenesis, brown fat cell differentiation, and response to lithium ion. It is located in the cytoplasm and nucleus, and is expressed in adipose tissue, CNS, genitourinary system, gut, and heart. It shares orthology with human FABP4. Biased expression is seen in subcutaneous and genital fat pads. FABP4 Protein, Mouse (His) is the recombinant mouse-derived FABP4 protein, expressed by E. coli , with N-His labeled tag. The total length of FABP4 Protein, Mouse (His) is 131 a.a., with molecular weight of ~15.63 kDa.

Background

The FABP4 protein possesses hormone receptor binding, long-chain fatty acid binding, and long-chain fatty acid transporter activities. It plays a role in transporting long-chain fatty acids and positively regulates cold-induced thermogenesis. It is involved in various processes, including brown fat cell differentiation, cellular response to lithium ion, and negative regulation of nitrogen compound metabolism. FABP4 is located in both the cytoplasm and nucleus and is expressed in several structures, including adipose tissue, the central nervous system, the genitourinary system, the gut, and the heart. It shares orthology with human FABP4 (fatty acid binding protein 4). The biased expression of FABP4 is observed in adult subcutaneous fat pad (RPKM 1709.3), genital fat pad adult (RPKM 1107.4), and four other tissues, as provided by the Alliance of Genome Resources in April 2022.

Biological Activity

Data is not available.

Species

Mouse

Source

E. coli

Tag

N-His

Accession

NP_077717.1 (C2-A132)

Gene ID

11770  [NCBI]

Molecular Construction
N-term
His
FABP4 (C2-A132)
Accession # NP_077717.1
C-term
Synonyms
Adipocyte-type fatty acid-binding protein; Fabp4; AFABP
AA Sequence

CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA

Molecular Weight

Approximately 15.63 kDa

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 0.2 M NaCl, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

FABP4 Protein, Mouse (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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FABP4 Protein, Mouse (His)
Cat. No.:
HY-P75215
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