FABP4 Protein, Mouse (His)
Based on 3 publication(s) in Google Scholar
The FABP4 protein binds hormone receptors, fatty acids, and transports them. It regulates thermogenesis, brown fat cell differentiation, and response to lithium ion. It is located in the cytoplasm and nucleus, and is expressed in adipose tissue, CNS, genitourinary system, gut, and heart. It shares orthology with human FABP4. Biased expression is seen in subcutaneous and genital fat pads. FABP4 Protein, Mouse (His) is the recombinant mouse-derived FABP4 protein, expressed by E. coli , with N-His labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The FABP4 protein binds hormone receptors, fatty acids, and transports them. It regulates thermogenesis, brown fat cell differentiation, and response to lithium ion. It is located in the cytoplasm and nucleus, and is expressed in adipose tissue, CNS, genitourinary system, gut, and heart. It shares orthology with human FABP4. Biased expression is seen in subcutaneous and genital fat pads. FABP4 Protein, Mouse (His) is the recombinant mouse-derived FABP4 protein, expressed by E. coli , with N-His labeled tag.
Background
The FABP4 protein possesses hormone receptor binding, long-chain fatty acid binding, and long-chain fatty acid transporter activities. It plays a role in transporting long-chain fatty acids and positively regulates cold-induced thermogenesis. It is involved in various processes, including brown fat cell differentiation, cellular response to lithium ion, and negative regulation of nitrogen compound metabolism. FABP4 is located in both the cytoplasm and nucleus and is expressed in several structures, including adipose tissue, the central nervous system, the genitourinary system, the gut, and the heart. It shares orthology with human FABP4 (fatty acid binding protein 4). The biased expression of FABP4 is observed in adult subcutaneous fat pad (RPKM 1709.3), genital fat pad adult (RPKM 1107.4), and four other tissues, as provided by the Alliance of Genome Resources in April 2022.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Commun Signal
Circulating adipocyte fatty acid-binding protein exacerbates LPS-induced neurotoxicity by crossing the disrupted blood-brain barrier and promoting neuronal apoptosis. [Abstract]2026 Jan 23;24(1):119. PMID: 41578320 -
Clin Transl Med
FABP4-mediated lipid droplet accumulation drives epithelial-mesenchymal transition and aggravates alveolar epithelial barrier disruption. [Abstract]2026 Jan;16(1):e70563. PMID: 41454478 -
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-His
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Accession
NP_077717.1 (C2-A132)
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Molecular Construction
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N-term
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His
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FABP4 (C2-A132)
Accession # NP_077717.1 -
C-term
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Protein Length
Full Length
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Synonyms
FABP4; Adipocyte Fatty Acid Binding Protein; Fatty Acid Binding Protein 4; Epididymis Secretory Protein Li 104; A-FABP; Adipocyte Lipid-Binding Protein; AP2; HEL-S-104; Adipocyte-Type Fatty Acid-Binding Protein; AFABP; Fatty Acid Binding Protein 4, Adipoc
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AA Sequence
CDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA
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Molecular Weight
Approximately 15-16 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 50 mM Tris, 0.2 M NaCl, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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