Fabp4 - fatty acid binding protein 4, adipocyte Gene

Also Known as Ap2; P15; ALBP; Lbpl; AFABP; 422/aP2; ALBP/Ap2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11770

Summary

Enables hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transporter activity. Involved in long-chain fatty acid transport and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; cellular response to lithium ion; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and heart. Orthologous to human FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Fabp4 Products (3)

mRNA Protein Name
NM_001409513.1 NP_001396442.1 fatty acid-binding protein, adipocyte isoform 2
NM_001409514.1 NP_001396443.1 fatty acid-binding protein, adipocyte isoform 3
NM_024406.4 NP_077717.1 fatty acid-binding protein, adipocyte isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone receptor binding IPI
IPI: Inferred from physical interaction
12077340 MGI
enables long-chain fatty acid binding IDA
IDA: Inferred from direct assay
12077340 MGI
enables long-chain fatty acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
12077340 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brown fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
acts upstream of or within cellular response to lithium ion IDA
IDA: Inferred from direct assay
15673614 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
1618860 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
15684432 MGI
acts upstream of or within cytokine production IMP
IMP: Inferred from mutant phenotype
15684432 MGI
involved in long-chain fatty acid transport IDA
IDA: Inferred from direct assay
12077340 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15684432 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
15684432 MGI
involved in positive regulation of cold-induced thermogenesis IGI
IGI: Inferred from genetic interaction
24603714 MGI
acts upstream of or within positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
15684432 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within white fat cell differentiation IDA
IDA: Inferred from direct assay
18492766 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17516629 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17516629 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fatty acid-binding protein, adipocyte

  • 3T3-L1 lipid-binding protein

  • P2 adipocyte protein

  • adipocyte lipid-binding protein

  • adipocyte protein aP2

  • adipocyte-type fatty acid-binding protein

  • fatty acid-binding protein 4

  • myelin P2 protein homolog

  • protein 422

Recombinant Fabp4 Proteins

Cat. No. Product Name Accession Purity
HY-P75215 FABP4 Protein, Mouse (His) NP_077717.1 (C2-A132) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75217 FABP4 Protein, Mouse (HEK293, His, solution) P04117 (M1-A132) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101903 BMS-309403 Inhibitor 99.91% Unkown
HY-101903A BMS-309403 sodium Inhibitor 99.89% Unkown
HY-161702 RO6806051 Inhibitor 99.82% Unkown
HY-121360 Cylindrospermopsin 98.76% Unkown
HY-161904 CDYL-IN-1 Inhibitor 99.80% Unkown
HY-N2445 Flavokawain C 99.79% Unkown
HY-160457 FABP4/5-IN-5 Inhibitor 98.10% Unkown
HY-163032 FABP4-IN-3 Inhibitor 99.64% Unkown
HY-148665 FABP-IN-2 Inhibitor 99.78% Unkown
HY-W012865 Tartronic acid ≥98.0% Unkown
HY-165607S MCB-22-174 99.78% Unkown
HY-149953 FABP4-IN-2 Inhibitor / Unkown
HY-RS16621 Fabp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172883 ABP/PPAR modulator 1 Modulator / Unkown
HY-161892 FABP4-IN-4 Inhibitor / Unkown
HY-172883A (E/Z)-ABP/PPAR modulator 1 Modulator 97.22% Unkown
HY-178471 FABP4/5-IN-6 Inhibitor / Unkown
HY-183836 FABP4/5-IN-7 Inhibitor / Unkown
HY-P10873 ST-CY14 / Unkown
HY-RS04660 FABP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160456 FABP4/5-IN-4 Inhibitor / Unkown
HY-RS23056 Fabp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011214 FABP4-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fabp4 NCBI NCBI:2167