Fibulin-3 Protein, Human (HEK293, His)

Fibulin-3 protein can bind to the EGF receptor (EGFR), stimulate EGFR autophosphorylation and activate downstream signaling pathways. It may act as a negative regulator of chondrocyte differentiation, affecting cell adhesion and migration. Fibulin-3 Protein, Human (HEK293, His) is the recombinant human-derived Fibulin-3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Fibulin-3 Protein, Human (HEK293, His) is 476 a.a., with molecular weight of 55-60 kDa.

Fibulin-3 protein exhibits the ability to bind to the EGF receptor (EGFR), stimulating EGFR autophosphorylation and subsequent activation of downstream signaling pathways. It is thought to have implications in cell adhesion and migration, and may function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, Fibulin-3 protein potentially regulates glial cell migration and differentiation, as well as influences the capacity of glial cells to support neuronal neurite outgrowth. It interacts with ECM1 and TIMP3 proteins.

Immobilized Human EFEMP1, His Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-EFEMP1 Antibody, hFc Tag with the EC₅₀ of ≤20 ng/mL determined by ELISA.

Human

HEK293

N-His

Q12805 (Q18-F493)

2202  [NCBI]

55-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.