FSH beta Protein, Mouse (HEK293, Fc)

FSH beta together with the alpha chain CGA form follicle-stimulating hormone or follicle-stimulating hormone (FSH), thus conferring biological specificity. FSH beta binds to FSHR on target cells, initiating key signaling pathways critical for follicle development and spermatogenesis. FSH beta Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FSH beta protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FSH beta Protein, Mouse (HEK293, Fc) is 111 a.a., with molecular weight of 50-60 kDa.

The FSH beta protein, in conjunction with the alpha chain CGA, forms follitropin, also known as follicle-stimulating hormone (FSH), conferring biological specificity to the hormone heterodimer. FSH beta binds to FSHR, a G protein-coupled receptor on target cells, initiating downstream signaling pathways. This hormone plays a pivotal role in follicle development and spermatogenesis within reproductive organs. Structurally, the active follitropin is a heterodimer comprised of an alpha chain/CGA, shared with other hormones, and a distinct beta chain/FSHB. The intricate assembly of FSH beta within the hormone heterodimer underscores its essential contribution to reproductive processes and hormonal signaling cascades.

Mouse

HEK293

C-hFc

Q60687 (H20-E130)

14308  [NCBI]

50-60 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.