FSH beta Protein, Mouse (HEK293, Fc)
Based on 1 Customer Validation
FSH beta together with the alpha chain CGA form follicle-stimulating hormone or follicle-stimulating hormone (FSH), thus conferring biological specificity. FSH beta binds to FSHR on target cells, initiating key signaling pathways critical for follicle development and spermatogenesis. FSH beta Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FSH beta protein, expressed by HEK293 , with C-hFc labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
FSH beta together with the alpha chain CGA form follicle-stimulating hormone or follicle-stimulating hormone (FSH), thus conferring biological specificity. FSH beta binds to FSHR on target cells, initiating key signaling pathways critical for follicle development and spermatogenesis. FSH beta Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FSH beta protein, expressed by HEK293 , with C-hFc labeled tag.
Background
The FSH beta protein, in conjunction with the alpha chain CGA, forms follitropin, also known as follicle-stimulating hormone (FSH), conferring biological specificity to the hormone heterodimer. FSH beta binds to FSHR, a G protein-coupled receptor on target cells, initiating downstream signaling pathways. This hormone plays a pivotal role in follicle development and spermatogenesis within reproductive organs. Structurally, the active follitropin is a heterodimer comprised of an alpha chain/CGA, shared with other hormones, and a distinct beta chain/FSHB. The intricate assembly of FSH beta within the hormone heterodimer underscores its essential contribution to reproductive processes and hormonal signaling cascades.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-hFc
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Accession
Q60687 (H20-E130)
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Molecular Construction
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N-term
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FSH beta (H20-E130)
Accession # Q60687 -
hFc
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
FSHB; Follitropin Beta Chain; Follicle Stimulating Hormone Subunit Beta; FSH-Beta; Follitropin Subunit Beta; FSH-B; Follicle Stimulating Hormone, Beta Polypeptide; Follicle Stimulating Hormone Beta Subunit; Follicle-Stimulating Hormone Beta Subunit; HH24;
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AA Sequence
HSCELTNITISVEKEECRFCISINTTWCAGYCYTRDLVYKDPARPNTQKVCTFKELVYETVRLPGCARHSDSLYTYPVATECHCGKCDSDSTDCTVRGLGPSYCSFSEMKE
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Molecular Weight
Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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