GH/Somatotropin Protein, Human (His)
Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-10*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-10*His labeled tag.
Background
The Somatotropin (GH) protein plays a pivotal role in growth control, exerting its primary influence on body growth by stimulating the liver and other tissues to secrete insulin-like growth factor 1 (IGF-1). GH serves as a potent regulator of both the differentiation and proliferation of myoblasts, contributing significantly to the overall growth and development of the organism. Additionally, it plays a crucial role in enhancing amino acid uptake and promoting protein synthesis in muscle and various tissues. Structurally, GH exists in various forms, including monomers, dimers, trimers, tetramers, and pentamers, either disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Furthermore, GH can form complexes with GH binding protein (GHBP) or with the alpha2-macroglobulin complex, underscoring its versatile molecular interactions that contribute to its multifaceted roles in growth regulation and tissue development.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-10*His
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Accession
P01241-1 (F27-F217)
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Molecular Construction
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N-term
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His
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GH (F27-F217)
Accession # P01241-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
GH1; Growth Hormone 1 Variant 2; Growth Hormone 1; Growth Hormone 1 Variant 1; GH-N; Growth Hormone 1 Isoform 1; GH; HCG1749481, Isoform CRA_aa; Pituitary Growth Hormone; Growth Hormone 1 Isoform 2; Somatotropin; HCG1749481, Isoform CRA_s; HGH-N; HCG17494
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AA Sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
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Predicted Molecular Mass
24.7 kDa
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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