1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Peptide Hormone & Neuropeptides
  4. Growth Hormone/Somatotropin
  5. GH/Somatotropin Protein, Human (His)

GH/Somatotropin Protein, Human (His)

Cat. No.: HY-P73085
Handling Instructions

Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-His labeled tag. The total length of GH/Somatotropin Protein, Human (His) is 191 a.a., with molecular weight of ~24.7 kDa.

For research use only. We do not sell to patients.

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Description

Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (His) is the recombinant human-derived GH/Somatotropin protein, expressed by E. coli , with N-His labeled tag. The total length of GH/Somatotropin Protein, Human (His) is 191 a.a., with molecular weight of ~24.7 kDa.

Background

The Somatotropin (GH) protein plays a pivotal role in growth control, exerting its primary influence on body growth by stimulating the liver and other tissues to secrete insulin-like growth factor 1 (IGF-1). GH serves as a potent regulator of both the differentiation and proliferation of myoblasts, contributing significantly to the overall growth and development of the organism. Additionally, it plays a crucial role in enhancing amino acid uptake and promoting protein synthesis in muscle and various tissues. Structurally, GH exists in various forms, including monomers, dimers, trimers, tetramers, and pentamers, either disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Furthermore, GH can form complexes with GH binding protein (GHBP) or with the alpha2-macroglobulin complex, underscoring its versatile molecular interactions that contribute to its multifaceted roles in growth regulation and tissue development.

Species

Human

Source

E. coli

Tag

N-His

Accession

P01241 (F27-F217)

Gene ID
Molecular Construction
N-term
His
GH (F27-F217)
Accession # P01241
C-term
Synonyms
Somatotropin; GH; GH-N; GH1
AA Sequence

FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF

Molecular Weight

Approximately 24.7 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

GH/Somatotropin Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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GH/Somatotropin Protein, Human (His)
Cat. No.:
HY-P73085
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