HER2/CD340 Protein, Cynomolgus (HEK293, hFc)
HER2/CD340 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived HER2/CD340 protein, expressed by HEK293, with C-hFc tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
HER2/CD340 Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived HER2/CD340 protein, expressed by HEK293, with C-hFc tag.
Background
The ErbB family consists of four separate plasma membrane-binding receptor tyrosine kinases. One of them is erbB-2, and the other members are erbB-1, erbB-3 (neuregulin-binding; Lack of kinase domains) and erbB-4. The receptor tyrosine-protein kinase erbB-2 is a protein normally found on cell membranes and is encoded by the ERBB2 gene. The human protein is also often referred to as HER 2 (Human epidermal growth factor receptor 2) or CD340 (differentiated cluster 340). HER2 has binding activity with Hsp90 protein, protein tyrosine kinase and ubiquitination protein. ErbB2 regulates differentiation and apoptosis of neural stem cells in the cochlear nucleus through PI3K/Akt pathway. HER2 is an oncogenic factor that is overexpressed in bladder cancer and activates the oncogenic signaling pathway, thereby promoting tumor cell survival/proliferation[1][2][3][4].
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-hFc
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Accession
XP_005584091.2 (T23-T652)
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Gene ID102146608
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Molecular Construction
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N-term
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HER2 (T23-T652)
Accession # XP_005584091.2 -
hFc
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C-term
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Protein Length
Partial
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Synonyms
ERBB2; P185erbB2; Prev. NGL; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog); HER2; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 Isoform C; Receptor Tyrosine-Protein Kinase ErbB-2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2; Proto-Oncogene C-ErbB-2; Neuroblastoma/Glioblastoma Derived Oncogene Homolog; Proto-Oncogene Neu; Receptor Tyrosine-Protein Kinase ErbB-2 Variant; P185(ErbB2); Truncated HER2 Splice Variant P100; C-ERB-2; Receptor Protein-Tyrosine Kinase; C-ERB2; Metastatic Lymph Node Gene 19; MLN-19; Alternative Protein ERBB2; HER-2; C-Erb B2/Neu Protein; CD340; CD340 Antigen; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; HER-2/Neu; Tyrosine Kinase-Type Cell Surface Receptor HER2; Herstatin; Neuro/Glioblastoma Derived Oncogene Homolog; VSCN2; Human Epidermal Growth Factor Receptor 2; MLN19; Metastatic Lymph Node Gene 19 Protein; TKR1; Erb-B2 Receptor Tyrosine Kinase 2; MLN 19
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AA Sequence
TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPVCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLRVFETLEEITGYLYISAWPDSLPDLSVLQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTRLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGTCQSCPINCTHSCVDLDDKGCPAEQRASPLT
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Predicted Molecular Mass
95.8 kDa
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Molecular Weight
Approximately 120-150 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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