IDO-2 Protein, Human (P.pastoris, His)
The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (P.pastoris, His) is the recombinant human-derived IDO-2 protein, expressed by P. pastoris , with N-His labeled tag.
- Species: Human
- Source: P. pastoris
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The IDO-2 protein plays a key role in cellular processes, catalyzing the initial and rate-limiting steps in the catabolism of the essential amino acid tryptophan in the kynurenine pathway. This enzymatic activity has been confirmed in multiple studies, establishing IDO-2 as a key regulator of tryptophan metabolism with important implications for immune regulation. IDO-2 Protein, Human (P.pastoris, His) is the recombinant human-derived IDO-2 protein, expressed by P. pastoris , with N-His labeled tag.
Background
Indoleamine 2,3-dioxygenase 2 (IDO-2) is an enzyme that catalyzes the first and rate-limiting step in the catabolism of the essential amino acid tryptophan along the kynurenine pathway. This pathway is crucial for the regulation of tryptophan metabolism and has implications in immune regulation. IDO-2's activity contributes to immune modulation by limiting tryptophan availability, which, in turn, affects immune cell function. While IDO-2 is involved in immune regulation, it may not play a significant role in tryptophan-related tumoral resistance, as suggested by certain studies.
Technical Parameters
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Species Human
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Source P. pastoris
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Tag N-His
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Accession
Q6ZQW0-1 (M1-G407)
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Molecular Construction
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N-term
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His
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IDO-2 (M1-G407)
Accession # Q6ZQW0-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
IDO2; Indoleamine 2,3-Dioxygenase-Like Protein 1; Prev. INDOL1; Alternative Protein IDO2; Indoleamine-Pyrrole 2,3-Dioxygenase-Like Protein 1; IDO-2; Indoleamine-Pyrrole 2,3 Dioxygenase-Like 1; Indoleamine 2,3-Dioxygenase 2; Indoleamine 2,3-Dioxygenase-Lik
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AA Sequence
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
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Predicted Molecular Mass
50.4 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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