IDO2 - indoleamine 2,3-dioxygenase 2 Gene

Also Known as INDOL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 169355

About IDO2

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:39,934,651-40,016,392 (from NCBI)

This gene has 3 transcripts (splice variants) and 91 orthologues. Biased expression in placenta (RPKM 9.5), liver (RPKM 2.8) and 3 other tissues.

Summary

Along with the Enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

IDO2 Products (2)

mRNA Protein Name
NM_194294.5 NP_919270.3 indoleamine 2,3-dioxygenase 2
NM_001395206.1 NP_001382135.1 indoleamine 2,3-dioxygenase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables indoleamine 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
17671174 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in tryptophan catabolic process to kynurenine IDA
IDA: Inferred from direct assay
17671174 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IDO2 Protein Structure

IDO

IDO: Indoleamine 2,3-dioxygenase (14 - 401)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

indoleamine 2,3-dioxygenase 2

  • indoleamine 2,3-dioxygenase-like 1 protein

  • indoleamine 2,3-dioxygenase-like protein 1

  • indoleamine-pyrrole 2,3 dioxygenase-like 1

  • indoleamine-pyrrole 2,3-dioxygenase-like protein 1

Recombinant IDO2 Proteins

Cat. No. Product Name Accession Purity
HY-P70863 IDO-2 Protein, Human (His) Q6ZQW0-1 (M1-G407) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71743 IDO-2 Protein, Human (P.pastoris, His) Q6ZQW0-1 (M1-G407) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100687 GNF-PF-3777 Inhibitor 98.03% Unkown
HY-145280 IDO1/2-IN-1 Inhibitor 98.06% Unkown
HY-151093 IDO2-IN-1 Inhibitor 98.10% Unkown
HY-112867 Amg-1 Inhibitor / Unkown
HY-184078 8-F-2-(Me-Pip-Me)-Tryptanthrin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IDO2 RGD RGD:1596771
Bos taurus IDO2 VGNC VGNC:30036
Mus musculus IDO2 MGD MGI:2142489
Canis familiaris IDO2 VGNC VGNC:41866
Macaca mulatta IDO2 VGNC VGNC:84005
Felis catus IDO2 VGNC VGNC:78513
Others IDO2 NCBI