LMTK3 Protein, Mouse (sf9, GST)
LMTK3 Protein, Mouse (sf9, GST) is the recombinant mouse-derived LMTK3, expressed by Sf9 insect cells , with GST labeled tag. ,
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
LMTK3 Protein, Mouse (sf9, GST) is the recombinant mouse-derived LMTK3, expressed by Sf9 insect cells , with GST labeled tag. ,
Background
LMTK3 is a protein kinase that phosphorylates ESR1 in vitro and protects it from proteasomal degradation. It may also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway, where it reduces PKC activity and AKT phosphorylation, thereby enhancing the binding of the transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Additionally, LMTK3 is involved in the endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852).
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag GST
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Accession
Q5XJV6 (K63-A484)
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Gene ID381983
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Protein Length
Partial
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Synonyms
LMTK3; AATYK3; Lemur Tyrosine Kinase 3; LMR3; TYKLM3; Protein Phosphatase 1, Regulatory Subunit 101; KIAA1883; Serine/Threonine-Protein Kinase LMTK3; PPP1R101; Non-Specific Serine/Threonine Protein Kinase
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AA Sequence
KRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYSPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKA
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Molecular Weight
Approximately 75 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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