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LRP-1 Cluster IV Protein, Human (CHO, His)

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LRP-1 Cluster IV Protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster IV Protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster IV Protein, Human (CHO, His) is the recombinant human-derived LRP-1 Cluster IV protein, expressed by CHO , with C-10*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: CHO
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Experimental Validation Results for LRP-1 Cluster IV Protein, Human (CHO, His)
  • Experimental Validation Results for LRP-1 Cluster IV Protein, Human (CHO, His)
  • LRP-1 Cluster IV Protein, Human (CHO, His) Product Image
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

LRP-1 Cluster IV Protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster IV Protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster IV Protein, Human (CHO, His) is the recombinant human-derived LRP-1 Cluster IV protein, expressed by CHO , with C-10*His labeled tag.

Background

LRP-1 Cluster IV Protein emerges as a multifunctional endocytic receptor, playing pivotal roles in both endocytosis and the phagocytosis of apoptotic cells. Its significance extends to essential functions in early embryonic development and cellular lipid homeostasis. Additionally, LRP-1 Cluster IV is actively involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the localized metabolism of complexes formed between plasminogen activators and their endogenous inhibitors. Acting as an LRPAP1 alpha-2-macroglobulin receptor, it further participates in various cellular events, including the endocytosis and subsequent spread of TAU/MAPT. Moreover, LRP-1 Cluster IV may modulate critical cellular processes such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling, and neurotransmission. Notably, in microbial infection, the protein functions as a receptor for Pseudomonas aeruginosa exotoxin A, highlighting its diverse and intricate roles in cellular physiology and host-pathogen interactions.

Verified Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Human LRP-1 Cluster IV at 1 μg/mL (100 μL/well) can bind Biotinylated Human LRPAP1 (HY-P76478). The ED50 for this effect is 0.5-1.5 ng/mL.

MCE Validation Data

  • Purity - SDS-PAGE

    Purity - SDS-PAGE

    ≥ 95%, as determined by reducing SDS-PAGE.

  • Bioactivity - ELISA

    Bioactivity - ELISA

    Measured by its binding ability in a functional ELISA. Immobilized Human LRP-1 Cluster IV at 1 μg/mL (100 μL/well) can bind Biotinylated Human LRPAP1 (HY-P76478). The ED50 for this effect is 1.235 ng/mL.

Technical Parameters

  • Species Human
  • Source CHO
  • Tag C-10*His
  • Accession

    Q07954-1 (S3332-D3779)

  • Gene ID
    4035
  • Molecular Construction
    • N-term
    • LRP-1 Cluster IV (S3332-D3779)
      Accession # Q07954-1
    • 10*His
    • C-term
  • Protein Length

    Partial Extracellular Domain

  • Synonyms

    LRP1; Apolipoprotein E Receptor; Prev. A2MR; TbetaR-V/LRP-1/IGFBP-3 Receptor; Prev. APR; Type V Tgf-Beta Receptor; APOER; Alternative Protein LRP1; Alpha-2-Macroglobulin Receptor; CD91 Antigen; IGFBP3R1; LRP1 Protein; IGFBP-3R; IGFBP3R; LRP1A; TGFBR5; CD91; LRP-1; LRP; DDH3; Prolow-Density Lipoprotein Receptor-Related Protein 1; KPA; Low Density Lipoprotein Receptor-Related Protein 1; LDL Receptor Related Protein 1; Transforming Growth Factor-β Receptor Type V

  • AA Sequence

    SNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSID

  • Predicted Molecular Mass

    51.5 kDa

  • Molecular Weight

    Approximately 60-88 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • 1/16

    MedChemExpress Validation
     Measured by its binding ability in a functional ELISA. Immobilized Human LRP-1 Cluster IV at 1 μg/mL (100 μL/well) can bind Biotinylated Human LRPAP1 (HY-P76478). The ED50 for this effect is 1.235 ng/mL.

  • LRP-1 Cluster IV Protein, Human (CHO, His) Product Image
    1/16
  • Experimental Validation Results for LRP-1 Cluster IV Protein, Human (CHO, His)
  • Experimental Validation Results for LRP-1 Cluster IV Protein, Human (CHO, His)
  • LRP-1 Cluster IV Protein, Human (CHO, His) Product Image