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  3. METRNL/Meteorin-like Protein, Human (His-SUMO)

METRNL/Meteorin-like Protein, Human (His-SUMO)

Cat. No.: HY-P71569
COA Handling Instructions

METRNL/meteorin-like protein is caused by hormonal changes caused by exercise or cold exposure, which increases energy expenditure. After exercise, it is expressed in skeletal muscle, whereas during cold exposure, it is expressed in adipose tissue. METRNL/Meteorin-like Protein, Human (His-SUMO) is the recombinant human-derived METRNL/Meteorin-like protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of METRNL/Meteorin-like Protein, Human (His-SUMO) is 266 a.a., with molecular weight of ~46.0 kDa.

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Description

METRNL/meteorin-like protein is caused by hormonal changes caused by exercise or cold exposure, which increases energy expenditure. After exercise, it is expressed in skeletal muscle, whereas during cold exposure, it is expressed in adipose tissue. METRNL/Meteorin-like Protein, Human (His-SUMO) is the recombinant human-derived METRNL/Meteorin-like protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of METRNL/Meteorin-like Protein, Human (His-SUMO) is 266 a.a., with molecular weight of ~46.0 kDa.

Background

METRNL/Meteorin-like protein is induced in response to hormonal changes triggered by exercise or exposure to cold, contributing to enhanced energy expenditure. Its expression is observed in skeletal muscle post-exercise and adipose tissue during cold exposure, and it circulates in the bloodstream. METRNL/Meteorin-like protein facilitates energy expenditure by promoting the browning of white fat depots and improving glucose tolerance. Interestingly, its thermogenic effects are not directly exerted on adipocytes but involve the stimulation of various immune cell subtypes. It induces an eosinophil-dependent increase in IL4 expression and facilitates the alternative activation of adipose tissue macrophages, crucial for the enhanced expression of thermogenic and anti-inflammatory gene programs in fat. METRNL/Meteorin-like protein is essential for certain cold-induced thermogenic responses, highlighting its role in metabolic adaptations to low temperatures.

Species

Human

Source

E. coli

Tag

N-SUMO;N-6*His

Accession

Q641Q3 (46Q-311D)

Gene ID
Molecular Construction
N-term
6*His-SUMO
METRNL (46Q-311D)
Accession # Q641Q3
C-term
Synonyms
Meteorin like glial cell differentiation regulator; Meteorin; glial cell differentiation regulator like; Meteorin-like protein; METRL_HUMAN; Metrnl
AA Sequence

QYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD

Molecular Weight

Approximately 46.0 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

METRNL/Meteorin-like Protein, Human (His-SUMO) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
METRNL/Meteorin-like Protein, Human (His-SUMO)
Cat. No.:
HY-P71569
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