Neurofascin Protein, Human (HEK293, hFc)
Neurofascin Protein, Human (HEK293, hFc) is the recombinant human-derived Neurofascin protein, expressed by HEK293, with C-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Neurofascin Protein, Human (HEK293, hFc) is the recombinant human-derived Neurofascin protein, expressed by HEK293, with C-hFc labeled tag.
Background
NFASC, a cell adhesion and ankyrin-binding protein, is implicated in various neural processes, including neurite extension, axonal guidance, synaptogenesis, myelination, and interactions between neurons and glial cells. It forms a horseshoe-shaped homodimer and is likely a component of the NFASC/NRCAM/ankyrin-G complex. NFASC associates with sodium channel beta-1 (SCN1B) and beta-3 (SCN3B) subunits, indicating its involvement in neuronal excitability and ion channel regulation. Additionally, NFASC interacts with GLDN/gliomedin, emphasizing its role in nodes of Ranvier and myelination. Furthermore, it engages with MYOC, suggesting potential connections to ocular functions or glaucoma. The multifaceted interactions of NFASC underscore its significance in orchestrating diverse cellular processes within the nervous system.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
O94856-12 (I25-Q939)
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Molecular Construction
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N-term
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Neurofascin (I25-Q939)
Accession # O94856-12 -
hFc
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C-term
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Protein Length
Partial Extracellular Domain
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Synonyms
NFASC; FLJ46866; Neurofascin; Neurofascin Homolog (Chicken); KIAA0756; Neurofascin Homolog; NRCAML; NEDCPMD; NF
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AA Sequence
IEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDLPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAYTNNQADIATQ
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Predicted Molecular Mass
130 kDa
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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