NPR1/NPRA Protein, Rat (HEK293, His)
Based on 1 Customer Validation
NPR1/NPRA Protein, Rat (HEK293, His) is the recombinant rat-derived NPR1/NPRA protein, expressed by HEK293, with C-His tag.
- Species: Rat
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
NPR1/NPRA Protein, Rat (HEK293, His) is the recombinant rat-derived NPR1/NPRA protein, expressed by HEK293, with C-His tag.
Background
NPR1/NPRA is a receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP, which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. It plays an essential role in regulating endothelial cell senescence and vascular aging. Upon activation by ANP or BNP, NPR1/NPRA stimulates the production of cyclic guanosine monophosphate (cGMP), which promotes vascular tone and volume homeostasis by activating protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis.
Technical Parameters
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Species Rat
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Source HEK293
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Tag C-8*His
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Accession
NP_036745 (S29-E469)
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Gene ID24603
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Protein Length
Extracellular Domain
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Synonyms
NPR1; ANPR-A; Prev. ANPRA; ANP-A; Prev. NPRA; GC-A; Guanylate Cyclase A; Natriuretic Peptide Receptor A/Guanylate Cyclase A (Atrionatriuretic Peptide Receptor A); GUCY2A; Natriuretic Peptide A Type Receptor; ANPa; Testicular Tissue Protein Li 20; Atrial N
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AA Sequence
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLE
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Predicted Molecular Mass
50.7 kDa
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Molecular Weight
Approximately 60-75 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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