P-Selectin Protein, Mouse (HEK293, His)

P-selectin, a Ca(2+)-dependent receptor on myeloid cells, binds specifically to carbohydrates on neutrophils and monocytes. It mediates interaction between activated endothelial cells or platelets and leukocytes through recognition of sialyl-Lewis X. P-selectin facilitates leukocyte rolling over vascular surfaces during inflammation by interacting with SELPLG and SNX17. It also promotes neutrophil adhesion and leukocyte rolling through interactions with SELPLG/PSGL1 and PODXL2, requiring sialyl-Lewis X and tyrosine sulfation on SELPLG. P-Selectin Protein, Mouse (HEK293, His) is the recombinant mouse-derived P-Selectin protein, expressed by HEK293 , with C-His labeled tag. The total length of P-Selectin Protein, Mouse (HEK293, His) is 668 a.a., with molecular weight of 110-130 kDa.

The P-selectin protein is a Ca(2+)-dependent receptor found on myeloid cells, which specifically binds to carbohydrates on neutrophils and monocytes. It plays a crucial role in mediating the interaction between activated endothelial cells or platelets and leukocytes. The ligand recognized by P-selectin is sialyl-Lewis X. P-selectin facilitates the rapid rolling of leukocytes over vascular surfaces during the initial stages of inflammation by interacting with SELPLG. It also interacts with SNX17. Moreover, P-selectin interacts with SELPLG/PSGL1 and PODXL2, promoting neutrophil adhesion and leukocyte rolling. This interaction requires the presence of the sialyl-Lewis X epitope on SELPLG and PODXL2, as well as specific tyrosine sulfation on SELPLG.

Mouse

HEK293

C-His

Q01102 (W42-A709)

20344  [NCBI]

110-130 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.