Selp - selectin, platelet Gene

Also Known as Grmp; CD62P; LECAM3; PADGEM; GMP-140

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20344

Summary

Enables calcium-dependent protein binding activity and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling and positive regulation of platelet activation. Acts upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (Selectin P). [provided by Alliance of Genome Resources, Apr 2022]

Selp Products (1)

mRNA	Protein	Name
NM_011347.2	NP_035477.1	P-selectin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	7524641	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7524641	MGI
enables sialic acid binding	IDA IDA: Inferred from direct assay	8562500	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	7688665	MGI
acts upstream of or within leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8557754	MGI
acts upstream of leukocyte migration	IGI IGI: Inferred from genetic interaction	17114491	MGI
acts upstream of leukocyte migration	IMP IMP: Inferred from mutant phenotype	17114491	MGI
acts upstream of or within leukocyte migration	IMP IMP: Inferred from mutant phenotype	15484189	MGI
acts upstream of or within leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	15956287	MGI
acts upstream of or within positive regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	17114491	MGI
acts upstream of or within positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	17114491	MGI
involved in positive regulation of leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	10894166	MGI
involved in positive regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	16514062	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8562500	MGI
located in membrane	IDA IDA: Inferred from direct assay	7688665	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
P-selectin	CD62 antigen-like family member P granule membrane protein 140 leukocyte-endothelial cell adhesion molecule 3 platelet activation dependent granule-external membrane protein

Recombinant Selp Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72408	P-selectin Protein, Mouse (Biotinylated, HEK293, Avi-His)	Q01102 (W42-A709)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73383	P-Selectin Protein, Mouse (HEK293, Fc)	Q01102 (W42-A709)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78349	P-Selectin Protein, Mouse (HEK293, His)	Q01102 (W42-A709)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12641	SELENOP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12647	SELP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17272	Selp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18579	Selenop Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23726	Selp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Selp	NCBI	NCBI:6403