SELP - selectin P Gene
Also Known as CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM
Species: Homo sapiens
About SELP
This gene has 7 transcripts (splice variants), 120 orthologues and 39 paralogues. Broad expression in urinary bladder (RPKM 9.3), appendix (RPKM 7.3) and 20 other tissues.
Summary
This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]
SELP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003005.4 | NP_002996.2 | P-selectin precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables calcium ion binding |
IDA
IDA: Inferred from direct assay
|
11081633 | GOA |
| enables fucose binding |
IDA
IDA: Inferred from direct assay
|
7680663 | GOA |
| enables heparin binding |
IDA
IDA: Inferred from direct assay
|
7680663 | GOA |
| enables integrin binding |
IDA
IDA: Inferred from direct assay
|
37184585 | GOA |
| enables lipopolysaccharide binding |
IMP
IMP: Inferred from mutant phenotype
|
16514062 | GOA |
| enables oligosaccharide binding |
IDA
IDA: Inferred from direct assay
|
7680663 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9129046 | GOA |
| enables sialic acid binding |
IDA
IDA: Inferred from direct assay
|
7680663 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
IMP
IMP: Inferred from mutant phenotype
|
28011641 | GOA |
| involved in cell-cell adhesion |
IDA
IDA: Inferred from direct assay
|
37184585 | GOA |
| involved in leukocyte cell-cell adhesion |
IDA
IDA: Inferred from direct assay
|
7680663 | GOA |
| involved in leukocyte tethering or rolling |
IMP
IMP: Inferred from mutant phenotype
|
28011641 | GOA |
| involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
IDA
IDA: Inferred from direct assay
|
17632516 | GOA |
| involved in regulation of integrin activation |
IMP
IMP: Inferred from mutant phenotype
|
17632516 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
16514062 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
9290466 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
28011641 | GOA |
| located in platelet alpha granule membrane |
IDA
IDA: Inferred from direct assay
|
15297306 | GOA |
SELP Protein Structure
Lectin_C: Lectin C-type domain (50 - 159)
Sushi: Sushi repeat (SCR repeat) (215 - 257)
Sushi: Sushi repeat (SCR repeat) (262 - 319)
Sushi: Sushi repeat (SCR repeat) (342 - 381)
Sushi: Sushi repeat (SCR repeat) (386 - 443)
Sushi: Sushi repeat (SCR repeat) (448 - 505)
Sushi: Sushi repeat (SCR repeat) (510 - 567)
Sushi: Sushi repeat (SCR repeat) (578 - 629)
Sushi: Sushi repeat (SCR repeat) (642 - 699)
Sushi: Sushi repeat (SCR repeat) (719 - 761)
- 0
- 200
- 400
- 600
- 830 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
P-selectin |
|
SELP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SELP | P16109 | SELPLG | Homo sapiens | Q14242 | 26627825 | |
|
Intra
|
SELP | P16109 | SELPLG | Homo sapiens | Q14242 | 11081633 |
Recombinant SELP Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70803 | P-selectin Protein, Human (HEK293, His) | P16109 (W42-A771, V640L) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73690 | P-Selectin Protein, Human (HEK293, Fc) | P16109 (W42-A771) | ≥ 85%, as determined by reducing SDS-PAGE. |
| HY-P78201 | P-Selectin Protein, Human (Biotinylated, HEK293, His-Avi) | P16109 (W42-A771) | ≥ 95%, as determined by Bis-Tris PAGE. |
SELP Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81737 | CD62P Antibody (YA1482) | FC, ELISA | Human |
| HY-P83529 | CD62P Antibody (YA3274) | WB, IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Intermittent Claudication |
|
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| Arteriosclerosis Obliterans |
|
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| Gray Platelet Syndrome |
|
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| Peripheral Vascular Disease |
|
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| Carotid Stenosis |
|
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| Blood Platelet Disease |
|
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| Venous Insufficiency |
|
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| Thrombosis |
|
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| Cerebrovascular Disease |
|
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| Quebec Platelet Disorder |
|
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| Thrombocytosis |
|
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| Antiphospholipid Syndrome |
|
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| Acute Myocardial Infarction |
|
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| Vascular Disease |
|
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| Platelet Aggregation, Spontaneous |
|
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| Maxillary Sinusitis |
|
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| Common Cold |
|
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| Thrombocytopenia Due To Platelet Alloimmunization |
|
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| Essential Thrombocythemia |
|
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| Mitral Valve Stenosis |
|
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| Atrial Fibrillation |
|
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| Ischemia |
|
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| Thrombocytopenic Purpura, Autoimmune |
|
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| Stroke, Ischemic |
|
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| Von Willebrand'S Disease |
|
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| Lipoprotein Quantitative Trait Locus |
|
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| Sickle Cell Disease |
|
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| Malaria |
|
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| Polyarteritis Nodosa |
|
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| Thrombotic Thrombocytopenic Purpura |
|
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| Thrombocytopenia |
|
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| Myocardial Infarction |
|
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| Hyperhomocysteinemia |
|
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| Vasculitis |
|
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| Arteriosclerosis |
|
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| Hemolytic-Uremic Syndrome |
|
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| Polycythemia Vera |
|
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| Pre-Eclampsia |
|
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| Atherosclerosis Susceptibility |
|
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| Purpura |
|
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| Cardiovascular System Disease |
|
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| Carotid Artery Thrombosis |
|
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| Hemoglobinuria |
|
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| Peritonitis |
|
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| Thrombophilia Due To Thrombin Defect |
|
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| Placental Insufficiency |
|
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| Legg-Calve-Perthes Disease |
|
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| Thrombophilia |
|
|
| Post-Thrombotic Syndrome |
|
|
| Leukocyte Adhesion Deficiency, Type I |
|
|
| Kawasaki Disease |
|
|
| Macular Degeneration, Age-Related, 9 |
|
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| Pancreatitis |
|
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| Proliferative Glomerulonephritis |
|
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| Bleeding Disorder, Platelet-Type, 11 |
|
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| Pulmonary Hypertension |
|
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| Intracranial Thrombosis |
|
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| Hypertension, Essential |
|
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| Qualitative Platelet Defect |
|
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| Carotid Artery Disease |
|
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| Pseudoxanthoma Elasticum |
|
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| Thrombasthenia |
|
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| Myelofibrosis |
|
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| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
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| Diabetes Mellitus |
|
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| Blood Coagulation Disease |
|
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| Acute Chest Syndrome |
|
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| Pulmonary Artery Disease |
|
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| Splenic Sequestration |
|
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| Adult Respiratory Distress Syndrome |
|
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| Type 2 Diabetes Mellitus |
|
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| Intracranial Embolism |
|
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| Heart Disease |
|
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| Occlusion Precerebral Artery |
|
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| Intermediate Coronary Syndrome |
|
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| Inflammatory Bowel Disease |
|
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| Intracranial Arteriosclerosis |
|
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| Carotid Artery Occlusion |
|
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| Colorectal Cancer |
|
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| Microvascular Complications Of Diabetes 1 |
|
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| Tangier Disease |
|
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| Myeloproliferative Neoplasm |
|
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| Chronic Venous Insufficiency |
|
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| Thrombophlebitis |
|
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| Peripheral Artery Disease |
|
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| Bernard-Soulier Syndrome |
|
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| Glanzmann Thrombasthenia 1 |
|
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| Asthma |
|
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| Vein Disease |
|
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| Uvulitis |
|
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| Sickle Cell Anemia |
|
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| Acute Promyelocytic Leukemia |
|
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| Systemic Lupus Erythematosus |
|
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| Dermatitis, Atopic |
|
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| Myopathy, Tubular Aggregate, 1 |
|
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| Sarcoidosis 1 |
|
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| Hemolytic Uremic Syndrome, Atypical 1 |
|
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| Cystic Fibrosis |
|
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| Leukemia, Chronic Myeloid |
|
|
| Patent Foramen Ovale |
|
|
| Nervous System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | SELP | VGNC | VGNC:64984 |
| Bos taurus | SELP | VGNC | VGNC:34424 |
| Mus musculus | SELP | MGD | MGI:98280 |
| Macaca mulatta | SELP | VGNC | VGNC:77157 |
| Canis familiaris | SELP | VGNC | VGNC:45985 |
| Rattus norvegicus | SELP | RGD | RGD:3656 |
| Others | SELP | NCBI |