PELI2 Protein, Human
PELI2 protein is an E3 ubiquitin ligase that links ubiquitin to substrate proteins. PELI2 Protein, Human is the recombinant human-derived PELI2 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
PELI2 protein is an E3 ubiquitin ligase that links ubiquitin to substrate proteins. PELI2 Protein, Human is the recombinant human-derived PELI2 protein, expressed by E. coli , with tag free.
PELI2, functioning as an E3 ubiquitin ligase, plays a crucial role in catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It actively participates in the Toll-like receptor (TLR) and interleukin-1 (IL-1) signaling pathways by interacting with the complex containing IRAK kinases and TRAF6. Specifically, PELI2 mediates IL1B-induced 'Lys-63'-linked polyubiquitination of IRAK1, and potentially 'Lys-48'-linked ubiquitination, contributing to the intricate regulation of downstream signaling events. Furthermore, PELI2 is implicated in LPS- and IL1B-induced NF-kappa-B activation, specifically via the MAP3K7-dependent pathway. Notably, PELI2's influence extends to the MAP kinase pathway, ultimately resulting in the activation of ELK1. These findings highlight PELI2 as a multifaceted regulator at the intersection of crucial immune signaling cascades, emphasizing its significance in modulating inflammatory responses and cellular signaling.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9HAT8 (F2-D420)
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Gene ID57161
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Molecular Construction
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N-term
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PELI2 (F2-D420)
Accession # Q9HAT8 -
C-term
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Protein Length
Partial
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Synonyms
PELI2; E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; RING-type E3 ubiquitin transferase pellino homolog 2
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AA Sequence
FSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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