PLAU/uPA Protein, Human (Biotinylated, HEK293, His-Avi)

uPA chain A Protein, a key player in the plasminogen activation system, selectively cleaves plasminogen, initiating fibrinolysis and contributing to tissue remodeling. Its precision underscores its role in regulating proteolytic activity, emphasizing its significance in the cascade of events leading to fibrinolysis and extracellular matrix remodeling in various physiological processes. PLAU/uPA Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived PLAU/uPA protein, expressed by HEK293 , with C-His, C-Avi labeled tag. The total length of PLAU/uPA Protein, Human (Biotinylated, HEK293, His-Avi) is 411 a.a., with molecular weight of 24-26 kDa (chain A) & 35-38 kDa (chain B) & 52-60 kDa (chain A & chain B), respectively.

uPA chain A, a key player in the plasminogen activation system, performs a critical role as it selectively cleaves the zymogen plasminogen to generate the enzymatically active form known as plasmin. This proteolytic activation is a pivotal step in fibrinolysis, where plasmin functions to degrade fibrin clots and contribute to tissue remodeling and repair. uPA chain A's precision in cleaving plasminogen underscores its significance in regulating the delicate balance of proteolytic activity, emphasizing its role as a key initiator in the cascade of events leading to fibrinolysis and other physiological processes involving extracellular matrix remodeling.

Human

HEK293

C-His;C-Avi

P00749 (S21-L431)

5328  [NCBI]

24-26 kDa (chain A)&35-38 kDa (chain B) &52-60 kDa (chain A&chain B)

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.