PLAU - plasminogen activator, urokinase Gene
Also Known as ATF; QPD; UPA; URK; u-PA; BDPLT5
Species: Homo sapiens
About PLAU
This gene has 5 transcripts (splice variants), 468 orthologues, 3 paralogues and is associated with 3 phenotypes. Broad expression in appendix (RPKM 23.1), urinary bladder (RPKM 22.7) and 23 other tissues.
Summary
This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
PLAU Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145031.3 | NP_001138503.2 | urokinase-type plasminogen activator isoform 2 |
| NM_001319191.2 | NP_001306120.2 | urokinase-type plasminogen activator isoform 3 |
| NM_002658.6 | NP_002649.2 | urokinase-type plasminogen activator isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
3501295 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in plasminogen activation |
IDA
IDA: Inferred from direct assay
|
25978044 | GOA |
| acts upstream of or within positive regulation of cell migration |
IDA
IDA: Inferred from direct assay
|
25168896 | GOA |
| involved in regulation of cell adhesion |
IDA
IDA: Inferred from direct assay
|
10722842 | GOA |
| involved in regulation of cell adhesion mediated by integrin |
IDA
IDA: Inferred from direct assay
|
8837777 | GOA |
| involved in regulation of signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
8837777 | GOA |
| involved in regulation of smooth muscle cell migration |
IDA
IDA: Inferred from direct assay
|
8837777 | GOA |
| involved in regulation of smooth muscle cell-matrix adhesion |
IDA
IDA: Inferred from direct assay
|
8837777 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
18835034 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
18835034 | GOA |
| part of protein complex involved in cell-matrix adhesion |
IPI
IPI: Inferred from physical interaction
|
24465541 | GOA |
| part of serine protease inhibitor complex |
IPI
IPI: Inferred from physical interaction
|
21199867 | GOA |
| part of serine-type endopeptidase complex |
IPI
IPI: Inferred from physical interaction
|
22285761 | GOA |
PLAU Protein Structure
Kringle: Kringle domain (70 - 151)
Trypsin: Trypsin (179 - 419)
- 0
- 100
- 200
- 300
- 400
- 431 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
urokinase-type plasminogen activator |
|
PLAU Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PLAU | P00749 | ADAM28 | Homo sapiens | Q9UKQ2 | 32296183 | |
|
Intra
|
PLAU | P00749 | PLAUR | Homo sapiens | Q03405-1 | 18376415 | |
|
Intra
|
PLAU | P00749 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
PLAU | P00749 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
PLAU | P00749 | APP | Homo sapiens | P05067 | 32814053 | |
|
Intra
|
PLAU | P00749 | SERPINE1 | Homo sapiens | P05121 | 33961781 |
Recombinant PLAU Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71050 | PLAU/uPA Protein, Human (HEK293, His, solution) | P00749-1 (S21-L431) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73467 | PLAU/uPA Protein, Human (HEK293, His) | NP_002649.1 (S21-L431) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78195 | PLAU/uPA Protein, Human (Biotinylated, HEK293, His-Avi) | P00749-1 (S21-L431) | ≥ 95%, as determined by Bis-Tris PAGE. |
PLAU Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83503 | uPA Antibody (YA3248) | WB, IHC-P | Human, Mouse, Rat |
| HY-P83503A | uPA Antibody (YA3248)(PBS only) | WB, IHC-P | Human, Mouse, Rat |
| HY-P83892 | PLAU Antibody (YA3589) | WB, ICC/IF, FC, ELISA | Human |
| HY-P83892A | PLAU Antibody (YA3589)(PBS only) | WB, ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Quebec Platelet Disorder |
|
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| Alzheimer Disease, Familial, 1 |
|
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| Alzheimer'S Disease 1 |
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| Ureter, Cancer Of |
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| Fibrosarcoma |
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| Dermatitis Herpetiformis |
|
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| Paroxysmal Nocturnal Hemoglobinuria |
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| Conjunctivochalasis |
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| Gynatresia |
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| Colorectal Cancer |
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| Venous Insufficiency |
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| Breast Disease |
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| Bullous Pemphigoid |
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| Thrombosis |
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| Transitional Cell Carcinoma |
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| Membranous Nephropathy |
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| Chondrosarcoma |
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| Ovarian Cancer |
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| Breast Ductal Carcinoma |
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| Prostate Cancer |
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| Intratubular Embryonal Carcinoma |
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| Lung Cancer |
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| Glioma |
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| Pulmonary Embolism |
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| Pancreatic Cancer |
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| Endometriosis |
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| Gastric Cancer |
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| Breast Cancer |
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| Pemphigus Vulgaris, Familial |
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| Aortic Aneurysm, Familial Abdominal, 1 |
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| Pneumoconiosis |
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| Glioblastoma |
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| Hepatocellular Carcinoma |
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| Anaplastic Astrocytoma |
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| Benign Meningioma |
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| Pre-Eclampsia |
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| Endometrial Cancer |
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| Bladder Cancer |
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| Melanoma |
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| Brain Cancer |
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| Lung Cancer Susceptibility 3 |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | PLAU | RGD | RGD:3343 |
| Macaca mulatta | PLAU | VGNC | VGNC:76162 |
| Mus musculus | PLAU | MGD | MGI:97611 |
| Felis catus | PLAU | VGNC | VGNC:68892 |
| Bos taurus | PLAU | VGNC | VGNC:32975 |
| Canis familiaris | PLAU | VGNC | VGNC:52017 |
| Others | PLAU | NCBI |