ADAM28 - ADAM metallopeptidase domain 28 Gene

Also Known as MDCL; MDC-L; eMDCII; ADAM 28; eMDC II

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10863

About ADAM28

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:24,294,069-24,359,014 (from NCBI)

This gene has 13 transcripts (splice variants), 247 orthologues and 20 paralogues. Biased expression in stomach (RPKM 21.4), gall bladder (RPKM 11.1) and 12 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with Other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

ADAM28 Products (3)

mRNA Protein Name
NM_001304351.2 NP_001291280.1 disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein
NM_014265.6 NP_055080.2 disintegrin and metalloproteinase domain-containing protein 28 isoform 1 preproprotein
NM_021777.5 NP_068547.2 disintegrin and metalloproteinase domain-containing protein 28 isoform 3 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables immunoglobulin receptor binding IPI
IPI: Inferred from physical interaction
12777399 GOA
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
12777399 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM28 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (28 - 155)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (204 - 399)

Disintegrin

Disintegrin: Disintegrin (416 - 490)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (493 - 576)

  • 0
  • 200
  • 400
  • 600
  • 775 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 28

  • epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

ADAM28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ADAM28 Q9UKQ2 PLAU Homo sapiens P00749
Y2H Array
32296183
Intra
ADAM28 Q9UKQ2 PLAU Homo sapiens P00749
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hyperostosis Cranialis Interna

  • HCIN

  • Hyperostosis Cranalis Interna
Epilepsy, Familial Temporal Lobe, 1

  • ETL1

  • Adpeaf

  • Adlte

  • Epilepsy, Partial, With Auditory Features

  • Autosomal Dominant Partial Epilepsy With Auditory Features

  • Epilepsy, Lateral Temporal Lobe, Autosomal Dominant

  • Familial Temporal Lobe Epilepsy 1

  • Partial Epilepsy With Auditory Features

  • Autosomal Dominant Lateral Temporal Lobe Epilepsy

  • Lateral Temporal Lobe Epilepsy Autosomal Dominant

  • Epilepsy, Temporal Lobe, Familial, Type 1
Hyperostosis

  • Hypertrophy Of Bone

  • Bone Hypertrophy

  • Bone Thickening

  • Periosteum Thickening
Asbestos-Related Lung Carcinoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00280 ADAM28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19498 Adam28 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25992 Adam28 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADAM28 VGNC VGNC:69486
Canis familiaris ADAM28 VGNC VGNC:37582
Felis catus ADAM28 VGNC VGNC:59582
Rattus norvegicus ADAM28 RGD RGD:727820
Mus musculus ADAM28 MGD MGI:105988
Others ADAM28 NCBI