REG-3 beta/REG3B Protein, Mouse
REG-3 beta/REG3B Protein, a bactericidal C-type lectin, combats intestinal Gram-positive and Gram-negative bacteria, except S.typhimurium. It inhibits S.enteritidis translocation, safeguarding against infection. Beyond antibacterial action, REG-3 beta functions hormonally, activating EXTL3 receptor for cell-specific signaling. In the pancreas, it notably stimulates cell proliferation. REG-3 beta/REG3B Protein, Mouse is the recombinant mouse-derived REG-3 beta/REG3B protein, expressed by E. coli , with no tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
REG-3 beta/REG3B Protein, a bactericidal C-type lectin, combats intestinal Gram-positive and Gram-negative bacteria, except S.typhimurium. It inhibits S.enteritidis translocation, safeguarding against infection. Beyond antibacterial action, REG-3 beta functions hormonally, activating EXTL3 receptor for cell-specific signaling. In the pancreas, it notably stimulates cell proliferation. REG-3 beta/REG3B Protein, Mouse is the recombinant mouse-derived REG-3 beta/REG3B protein, expressed by E. coli , with no tag.
REG-3 beta/REG3B, a bactericidal C-type lectin, exhibits antimicrobial properties against various intestinal Gram-positive and Gram-negative bacteria, with the exception of S.typhimurium. Its potential role in protecting against S.enteritidis infection involves inhibiting the translocation of the pathogen from the gut lumen into intestinal and extraintestinal tissues. Beyond its antibacterial function, REG-3 beta acts as a hormone in response to diverse stimuli. When secreted by different cell types, it activates its receptor EXTL3, initiating cell-specific signaling pathways. Notably, in the pancreas, REG-3 beta has the ability to stimulate cell proliferation.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag Tag Free
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Accession
P35230 (I38-G175)
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Gene ID18489
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Molecular Construction
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N-term
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REG3B (I38-G175)
Accession # P35230 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
Regenerating islet-derived protein 3-beta; REG-3-beta; Pancreatitis-associated protein 1; Regenerating islet-derived protein III-beta ; Reg III-beta; Regenerating islet-derived protein 3-beta 16.5 kDa form; Regenerating islet-derived protein 3-beta 15 kDa
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AA Sequence
ISCPKGSQAYGSYCYALFQIPQTWFDAELACQKRPGGHLVSVLNSAEASFLSSMVKRTGNSYQYTWIGLHDPTLGAEPNGGGWEWSNNDVMNYFNWERNPSTALDRAFCGSLSRASGFLKWRDMTCEVKLPYVCKFTG
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Predicted Molecular Mass
15.6 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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