RP105/CD180 Protein, Mouse (HEK293, His)
The RP105/CD180 protein is a key mediator in the B cell innate immune response to bacterial lipopolysaccharide (LPS), possibly synergizing with MD-1 and TLR4.Its participation activates NF-kappa-B and initiates immune signaling pathways. RP105/CD180 Protein, Mouse (HEK293, His) is the recombinant mouse-derived RP105/CD180 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The RP105/CD180 protein is a key mediator in the B cell innate immune response to bacterial lipopolysaccharide (LPS), possibly synergizing with MD-1 and TLR4.Its participation activates NF-kappa-B and initiates immune signaling pathways. RP105/CD180 Protein, Mouse (HEK293, His) is the recombinant mouse-derived RP105/CD180 protein, expressed by HEK293 , with C-His labeled tag.
Background
The RP105/CD180 protein emerges as a crucial mediator in the innate immune response to bacterial lipopolysaccharide (LPS) within B-cells, potentially collaborating with MD-1 and TLR4 in this process. Its involvement leads to the activation of NF-kappa-B, underscoring its role in initiating immune signaling pathways. Additionally, RP105/CD180 is implicated in the life/death decision of B-cells, suggesting a regulatory function in cellular survival processes. Structurally, it forms an M-shaped tetramer consisting of two CD180-LY86 heterodimers, highlighting its complex architecture. Further exploration of the intricate interactions between RP105/CD180, MD-1, and TLR4, as well as its role in the survival dynamics of B-cells, could provide deeper insights into its significance in the immune response and cellular decision-making processes.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-His
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Accession
Q62192 (M1-S626)
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Molecular Construction
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N-term
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RP105 (M1-S626)
Accession # Q62192 -
His
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C-term
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Protein Length
Partial Extracellular Domain
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Synonyms
CD180; Ly78; Prev. LY64; Lymphocyte Antigen 64; RP105; Lymphocyte Antigen 64 (Mouse) Homolog, Radioprotective, 105kD; CD180 Antigen; Lymphocyte Antigen-64, Radioprotective, 105kDa; CD180 Molecule; Radioprotective 105 KDa Protein
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AA Sequence
MAPDISCFFLVALFLASCRATTSSDQKCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTLSCS
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Predicted Molecular Mass
69.4 kDa
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Molecular Weight
Approximately 80-110 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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