RP105/CD180 Protein, Mouse (HEK293, His)

The RP105/CD180 protein is a key mediator in the B cell innate immune response to bacterial lipopolysaccharide (LPS), possibly synergizing with MD-1 and TLR4.Its participation activates NF-kappa-B and initiates immune signaling pathways. RP105/CD180 Protein, Mouse (HEK293, His) is the recombinant mouse-derived RP105/CD180 protein, expressed by HEK293 , with C-His labeled tag.

The RP105/CD180 protein emerges as a crucial mediator in the innate immune response to bacterial lipopolysaccharide (LPS) within B-cells, potentially collaborating with MD-1 and TLR4 in this process. Its involvement leads to the activation of NF-kappa-B, underscoring its role in initiating immune signaling pathways. Additionally, RP105/CD180 is implicated in the life/death decision of B-cells, suggesting a regulatory function in cellular survival processes. Structurally, it forms an M-shaped tetramer consisting of two CD180-LY86 heterodimers, highlighting its complex architecture. Further exploration of the intricate interactions between RP105/CD180, MD-1, and TLR4, as well as its role in the survival dynamics of B-cells, could provide deeper insights into its significance in the immune response and cellular decision-making processes.

Mouse

HEK293

C-His

Q62192 (M1-S626)

17079  [NCBI]

Partial

MAPDISCFFLVALFLASCRATTSSDQKCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTLSCS

Approximately 80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.