RYBP Protein, Human (sf9, His-GST)

RYBP Protein, a crucial regulatory factor, complexes with metalloproteinases like collagenases, inhibiting their activity by irreversibly binding to catalytic zinc cofactors. This interaction, notably with MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9, highlights RYBP's pivotal role in finely regulating extracellular matrix remodeling and proteolytic processes across diverse physiological contexts. RYBP Protein, Human (sf9, His-GST) is the recombinant human-derived RYBP protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of RYBP Protein, Human (sf9, His-GST) is 228 a.a., with molecular weight of ~58 kDa.

TIMP-4, a key regulatory protein, forms complexes with metalloproteinases, including collagenases, exerting its inhibitory effect by irreversibly binding to their catalytic zinc cofactors. This interaction is known to specifically impact metalloproteinases such as MMP-1, MMP-2, MMP-3, MMP-7, and MMP-9. Through this binding mechanism, TIMP-4 plays a crucial role in modulating the activity of these metalloproteinases, contributing to the fine-tuned regulation of extracellular matrix remodeling and proteolytic processes in various physiological contexts.

Human

Sf9 insect cells

N-His;N-GST

Q8N488 (M1-F228)

23429  [NCBI]

Approximately 58 kDa

Greater than 85% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.