RYBP - RING1 and YY1 binding protein Gene

Also Known as AAP1; DEDAF; YEAF1; APAP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23429

About RYBP

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,374,593-72,446,623 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 232 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 20.7), testis (RPKM 18.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and transcription coregulator activity. Involved in several processes, including histone H2A monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. Colocalizes with PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

RYBP Products (1)

mRNA	Protein	Name
NM_012234.6	NP_036366.3	RING1 and YY1-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables nucleic acid binding	EXP EXP: Inferred from Experiment	19170609	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	16943429	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	27060496	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27060496	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	27060496	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	16943429	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27060496	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RYBP Protein Structure

zf-RanBP

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
RING1 and YY1-binding protein	DED-associated factor

RYBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RYBP	Q8N488	NF2	Homo sapiens	P35240-4	Validated Y2H	32814053
Intra	RYBP	Q8N488	NF2	Homo sapiens	P35240-4	Y2H Pooling	32814053
Intra	RYBP	Q8N488	NF2	Homo sapiens	P35240-4	Y2H Array	32814053
Intra	RYBP	Q8N488	COMT	Homo sapiens	P21964-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	COMT	Homo sapiens	P21964-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	COMT	Homo sapiens	P21964-2	Y2H Array	32814053
Intra	RYBP	Q8N488	MAT2A	Homo sapiens	P31153	Validated Y2H	32814053
Intra	RYBP	Q8N488	MAT2A	Homo sapiens	P31153	Y2H Array	32814053
Intra	RYBP	Q8N488	MAT2A	Homo sapiens	P31153	Y2H Pooling	32814053
Intra	RYBP	Q8N488	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	RYBP	Q8N488	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	RYBP	Q8N488	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	RYBP	Q8N488	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	RYBP	Q8N488	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	RYBP	Q8N488	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	RYBP	Q8N488	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	RYBP	Q8N488	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	RYBP	Q8N488	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	RYBP	Q8N488	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
Intra	RYBP	Q8N488	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
Intra	RYBP	Q8N488	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
Intra	RYBP	Q8N488	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
Intra	RYBP	Q8N488	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	XAGE1A	Homo sapiens	Q9HD64	Validated Y2H	32296183
Cross	RYBP	Q8N488	P0C6X7-PRO_0000037319	Human SARS coronavirus	P0C6X7-PRO_0000037319	Lumier	22046132
Cross	RYBP	Q8N488	P0C6X7-PRO_0000037319	Human SARS coronavirus	P0C6X7-PRO_0000037319	Y2H Pooling	22046132
Intra	RYBP	Q8N488	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	RYBP	Q8N488	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	RYBP	Q8N488	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	RYBP	Q8N488	TGM2	Homo sapiens	P21980-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	TGM2	Homo sapiens	P21980-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	TGM2	Homo sapiens	P21980-2	Y2H Array	32814053
Intra	RYBP	Q8N488	F8	Homo sapiens	P00451-2	Y2H Array	32814053
Intra	RYBP	Q8N488	F8	Homo sapiens	P00451-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	F8	Homo sapiens	P00451-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	q9p1n4_human	Homo sapiens	Q9P1N4	Y2H Array	32814053
Intra	RYBP	Q8N488	q9p1n4_human	Homo sapiens	Q9P1N4	Y2H Pooling	32814053
Intra	RYBP	Q8N488	q9p1n4_human	Homo sapiens	Q9P1N4	Validated Y2H	32814053
Intra	RYBP	Q8N488	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	RYBP	Q8N488	TDP1	Homo sapiens	Q9NUW8	Y2H Array	32814053
Intra	RYBP	Q8N488	TDP1	Homo sapiens	Q9NUW8	Y2H Pooling	32814053
Intra	RYBP	Q8N488	TDP1	Homo sapiens	Q9NUW8	Validated Y2H	32814053
Intra	RYBP	Q8N488	UBC	Homo sapiens	P0CG48	Pull Down	17070805
Intra	RYBP	Q8N488	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	17070805
Intra	RYBP	Q8N488	SRP9	Homo sapiens	P49458	Y2H Pooling	32814053
Intra	RYBP	Q8N488	SRP9	Homo sapiens	P49458	Validated Y2H	32814053
Intra	RYBP	Q8N488	SRP9	Homo sapiens	P49458	Y2H Array	32814053
Intra	RYBP	Q8N488	PKM	Homo sapiens	P14618	Validated Y2H	32814053
Intra	RYBP	Q8N488	PKM	Homo sapiens	P14618	Y2H Array	32814053
Intra	RYBP	Q8N488	PKM	Homo sapiens	P14618	Y2H Pooling	32814053
Intra	RYBP	Q8N488	TP53	Homo sapiens	P04637	Anti Bait CoIP	34316702
Intra	RYBP	Q8N488	TP53	Homo sapiens	P04637	Anti Tag CoIP	19098711
Intra	RYBP	Q8N488	TP53	Homo sapiens	P04637	Anti Bait CoIP	19098711
Intra	RYBP	Q8N488	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	19098711
Intra	RYBP	Q8N488	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	19098711
Intra	RYBP	Q8N488	MDM2	Homo sapiens	Q00987	Pull Down	19098711
Intra	RYBP	Q8N488	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RYBP	Q8N488	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RYBP	Q8N488	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RYBP	Q8N488	FUS	Homo sapiens	P35637	Anti Bait CoIP	34316702
Intra	RYBP	Q8N488	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	RYBP	Q8N488	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	RYBP	Q8N488	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	RYBP	Q8N488	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	RYBP	Q8N488	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	RYBP	Q8N488	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	RYBP	Q8N488	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RYBP	Q8N488	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RYBP	Q8N488	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587-2	Imaging	17070805
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587-2	Anti Tag CoIP	28514442
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587-2	Anti Tag CoIP	17070805
Intra	RYBP	Q8N488	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	RYBP	Q8N488	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	RYBP	Q8N488	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Anti Bait CoIP	34316702
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	TAP	27705803
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	28514442
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Y2H Prey Pooling	32296183
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Validated Y2H	32296183
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	Y2H Array	32296183
Intra	RYBP	Q8N488	RNF2	Homo sapiens	Q99496	TAP	24981860
Intra	RYBP	Q8N488	SNCB	Homo sapiens	Q16143	Validated Y2H	32814053
Intra	RYBP	Q8N488	SNCB	Homo sapiens	Q16143	Y2H Array	32814053
Intra	RYBP	Q8N488	SNCB	Homo sapiens	Q16143	Y2H Pooling	32814053
Intra	RYBP	Q8N488	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	RYBP	Q8N488	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	RYBP	Q8N488	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	RYBP	Q8N488	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	RYBP	Q8N488	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	RYBP	Q8N488	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	RYBP	Q8N488	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Intra	RYBP	Q8N488	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	RYBP	Q8N488	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Array	25416956
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Array	32296183
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	TAP	27705803
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Pooling	16189514
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Anti Bait CoIP	34316702
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Pull Down	16943429
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Prey Pooling	25416956
Intra	RYBP	Q8N488	RING1	Homo sapiens	Q06587	Y2H Prey Pooling	32296183
Intra	RYBP	Q8N488	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
Cross	RYBP	Q8N488	Trpm7	Mus musculus	Q923J1	Anti Tag CoIP	24855944
Cross	RYBP	Q8N488	Trpm7	Mus musculus	Q923J1	IF	24855944
Intra	RYBP	Q8N488	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	RYBP	Q8N488	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	RYBP	Q8N488	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053
Intra	RYBP	Q8N488	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	RYBP	Q8N488	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	RYBP	Q8N488	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RYBP Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P74590	RYBP Protein, Human (sf9, His-GST)	Q8N488 (M1-F228)	≥ 85%, as determined by reducing SDS-PAGE.

RYBP Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82052	RYBP Antibody (YA1797)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pontocerebellar Hypoplasia, Type 13	PCH13 Pontocerebellar Hypoplasia Type 13 Pontocerebellar Hypoplasia 13 Doid:0112332 Hypoplasia, Pontocerebellar, Type 13
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12366	RYBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18972	Rybp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RYBP	MGD	MGI:1929059
Rattus norvegicus	RYBP	RGD	RGD:1307077
Bos taurus	RYBP	VGNC	VGNC:106910
Macaca mulatta	RYBP	VGNC	VGNC:84088
Canis familiaris	RYBP	VGNC	VGNC:58331
Felis catus	RYBP	VGNC	VGNC:102696
Others	RYBP	NCBI