RYBP - RING1 and YY1 binding protein Gene

Homo sapiens

Also known as AAP1; DEDAF; YEAF1; APAP-1

Gene ID: 23429 | Gene type: protein coding

About RYBP

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,374,593-72,446,623 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 232 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 20.7), testis (RPKM 18.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and transcription coregulator activity. Involved in several processes, including histone H2A monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. Colocalizes with PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

RYBP Products(1)

mRNA	Protein	Name
NM_012234.6	NP_036366.3	RING1 and YY1-binding protein

RYBP Protein Structure

zf-RanBP

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

RING1 and YY1-binding protein

DED-associated factor

Recombinant RYBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74590	RYBP Protein, Human (sf9, His-GST)	Q8N488 (M1-F228)	≥95%

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 13

PCH13	Pontocerebellar Hypoplasia Type 13
Pontocerebellar Hypoplasia 13	Doid:0112332
Hypoplasia, Pontocerebellar, Type 13

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12366	RYBP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RYBP	MGD	MGI:1929059
Rattus norvegicus	RYBP	RGD	RGD:1307077
Bos taurus	RYBP	VGNC	VGNC:106910
Macaca mulatta	RYBP	VGNC	VGNC:84088
Canis familiaris	RYBP	VGNC	VGNC:58331
Felis catus	RYBP	VGNC	VGNC:102696
Others	RYBP	NCBI