Trpm7 - transient receptor potential cation channel, subfamily M, member 7 Gene

Also Known as CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58800

Summary

Enables Calcium Channel activity; cytoskeletal protein binding activity; and kinase activity. Acts upstream of or within several processes, including calcium ion transport; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in plasma membrane and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]

Trpm7 Products (2)

mRNA Protein Name
NM_001164325.1 NP_001157797.1 transient receptor potential cation channel subfamily M member 7 isoform 2
NM_021450.2 NP_067425.2 transient receptor potential cation channel subfamily M member 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
16407977 MGI
enables calcium channel activity IDA
IDA: Inferred from direct assay
16407977 MGI
enables kinase activity IDA
IDA: Inferred from direct assay
16407977 MGI
enables myosin binding IPI
IPI: Inferred from physical interaction
16407977 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16407977 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
29203869 MGI
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
28696294 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actomyosin structure organization IDA
IDA: Inferred from direct assay
16407977 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
16407977 MGI
acts upstream of or within calcium-dependent cell-matrix adhesion IDA
IDA: Inferred from direct assay
16407977 MGI
involved in intracellular magnesium ion homeostasis IMP
IMP: Inferred from mutant phenotype
21045827 MGI
involved in magnesium ion transmembrane transport IDA
IDA: Inferred from direct assay
11385574 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
16407977 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
30108148 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
16407977 MGI
involved in zinc ion transport IDA
IDA: Inferred from direct assay
28696294 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
28696294 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24855944 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16407977 MGI
located in ruffle IDA
IDA: Inferred from direct assay
16407977 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 7

  • channel-kinase 1

  • long transient receptor potential channel 7

  • transient receptor potential M7

  • transient receptor potential-phospholipase C-interacting kinase

  • transient receptor potential-related protein, ChaK

Trpm7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Trpm7 Q923J1 Ddb1 Mus musculus Q3U1J4
Anti Tag CoIP
24855944
Cross
Trpm7 Q923J1 DDX3X Homo sapiens O00571
Anti Bait CoIP
24855944
Intra
Trpm7 Q923J1 Actb Mus musculus P60710
Anti Tag CoIP
16407977
Intra
Trpm7 Q923J1 Actb Mus musculus P60710
Anti Tag CoIP
24855944
Intra
Trpm7 Q923J1 Myh9 Mus musculus Q8VDD5
Anti Tag CoIP
16407977
Intra
Trpm7 Q923J1 Myh9 Mus musculus Q8VDD5
Protein Kinase Assay
16407977
Intra
Trpm7 Q923J1 Myh9 Mus musculus Q8VDD5
Anti Tag CoIP
24855944
Cross
Trpm7 Q923J1 RYBP Homo sapiens Q8N488
Pull Down
24855944
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168608 TRPM7-IN-1 Inhibitor 98.83% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm7 NCBI NCBI:54822