SCLY Protein, Human (His)

SCLY protein plays an important role in selenium metabolism by catalyzing the decomposition of L-selenocysteine to produce L-alanine and elemental selenium. This enzymatic process is critical for regulating intracellular selenium utilization and recycling. SCLY Protein, Human (His) is the recombinant human-derived SCLY protein, expressed by E. coli , with N-6*His labeled tag. The total length of SCLY Protein, Human (His) is 445 a.a., with molecular weight of 50-55 kDa.

Selenocysteine lyase (SCLY) is an enzyme that plays a crucial role in the decomposition of L-selenocysteine. Specifically, SCLY catalyzes the reaction that breaks down L-selenocysteine into L-alanine and elemental selenium. This enzymatic activity is significant in selenium metabolism, as it contributes to the release of selenium from selenoproteins and its subsequent utilization in various cellular processes. Selenocysteine is a unique amino acid that incorporates selenium into proteins, and its decomposition by SCLY is essential for selenium recycling and maintaining cellular selenium homeostasis. It has to highlight SCLY's specific role in the metabolic processing of selenocysteine, shedding light on its importance in selenium biology and the regulation of cellular selenium levels.

Human

E. coli

N-6*His

Q96I15 (M1-A445)

51540  [NCBI]

MEAAVAPGRDAPAPAASQPSGCGKHNSPERKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKVSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLMASVGAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVDLVVQDLKQAVAQLEDQA

50-55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.