SCLY Protein, Human (His)
SCLY protein plays an important role in selenium metabolism by catalyzing the decomposition of L-selenocysteine to produce L-alanine and elemental selenium. This enzymatic process is critical for regulating intracellular selenium utilization and recycling. SCLY Protein, Human (His) is the recombinant human-derived SCLY protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
SCLY protein plays an important role in selenium metabolism by catalyzing the decomposition of L-selenocysteine to produce L-alanine and elemental selenium. This enzymatic process is critical for regulating intracellular selenium utilization and recycling. SCLY Protein, Human (His) is the recombinant human-derived SCLY protein, expressed by E. coli , with N-6*His labeled tag.
Selenocysteine lyase (SCLY) is an enzyme that plays a crucial role in the decomposition of L-selenocysteine. Specifically, SCLY catalyzes the reaction that breaks down L-selenocysteine into L-alanine and elemental selenium. This enzymatic activity is significant in selenium metabolism, as it contributes to the release of selenium from selenoproteins and its subsequent utilization in various cellular processes. Selenocysteine is a unique amino acid that incorporates selenium into proteins, and its decomposition by SCLY is essential for selenium recycling and maintaining cellular selenium homeostasis. It has to highlight SCLY's specific role in the metabolic processing of selenocysteine, shedding light on its importance in selenium biology and the regulation of cellular selenium levels.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q96I15-1 (M1-A445)
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Molecular Construction
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N-term
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6*His
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SCLY (M1-A445)
Accession # Q96I15-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
SCLY; HSCL; Selenocysteine Lyase; Putative Selenocysteine Lyase; SCL; Alternative Protein SCLY
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AA Sequence
MEAAVAPGRDAPAPAASQPSGCGKHNSPERKVYMDYNATTPLEPEVIQAMTKAMWEAWGNPSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVKHFHANQTSKGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKVSGQAEVDDILAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGKQRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTPMIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCNFSIRGPRLQGHVVLAQCRVLMASVGAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGRSTTRAEVDLVVQDLKQAVAQLEDQA
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Predicted Molecular Mass
50.3 kDa
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Molecular Weight
Approximately 50-55 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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