SCLY - selenocysteine lyase Gene

Also Known as SCL; hSCL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51540

About SCLY

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,061,001-238,099,413 (from NCBI)

This gene has 21 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 6.4), liver (RPKM 4.7) and 25 other tissues.

Summary

Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]

SCLY Products (1)

mRNA Protein Name
NM_016510.7 NP_057594.5 selenocysteine lyase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCLY Protein Structure

Aminotran_5

Aminotran_5: Aminotransferase class-V (40 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

selenocysteine lyase

SCLY Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCLY Q96I15 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
Intra
SCLY Q96I15 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
Intra
SCLY Q96I15 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SCLY Proteins

Cat. No. Product Name Accession Purity
HY-P71280 SCLY Protein, Human (His) Q96I15-1 (M1-A445) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Glomerulonephritis

  • Bright'S Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0361 Aspartame 99.70% Unkown
HY-17474 Parecoxib Inhibitor 99.29% Yes
HY-132587 Fitusiran 98.70% Unkown
HY-17474A Parecoxib Sodium Inhibitor 99.82% Yes
HY-B0561R Spironolactone (Standard) 98.55% Unkown
HY-17509 Deracoxib 99.96% Unkown
HY-132587A Fitusiran sodium 95.08% Unkown
HY-B0455A Lomefloxacin 99.99% Unkown
HY-B0318A Metronidazole hydrochloride 98.44% Yes
HY-B1341 Norethynodrel Activator 90.53% Unkown
HY-132587C Fitusiran sodium scrambled negative control Activator / Unkown
HY-132587D FAM labled Fitusiran sodium / Unkown
HY-132587E Cy3 labled Fitusiran sodium / Unkown
HY-B0455AR Lomefloxacin (Standard) Inhibitor / Unkown
HY-B0455B Lomefloxacin (aspartate) Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99590 Sotatercept 99.94% Unkown

Clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Phase
HY-14718 Resminostat Inhibitor 99.44% Phase 4
HY-14398GL Celecoxib (GMP Like) Inhibitor / Phase 4
HY-170554 ABBV-706 Inhibitor 99.71% Phase 3
HY-132257 Rovalpituzumab tesirine Inhibitor 97.47% Phase 3
HY-U00232 Bidisomide Ligand 99.62% Phase 3
HY-136657 SC-43 99.01% Phase 2
HY-16012 Domatinostat tosylate 99.66% Phase 2
HY-106395 Telinavir Inhibitor 98.16% Phase 2
HY-100934 SC-9 Activator 99.33% Phase 2
HY-14908A Vidofludimus hemicalcium / Phase 2
HY-19046 AGN-2979 hydrochloride Inhibitor / Phase 2
HY-19080 SC-45662 Inhibitor / Phase 2
HY-19500 SC-75416 Inhibitor / Phase 2
HY-16451 SC-49483 / Phase 2
HY-19897 4SC-203 Inhibitor 98.98% Phase 1
HY-112739 SC-41930 Agonist / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99886 Pexelizumab Inhibitor 99.0% Phase 3

Pre-clinical Phase

Bioactive Molecules (170)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18749 SC79 Activator 98.0% Unkown
HY-107410 SC-26196 Inhibitor 99.66% Unkown
HY-10496 SC75741 Inhibitor 99.24% Unkown
HY-148559 4A3-SC8 99.93% Unkown
HY-15614 SC144 99.48% Unkown
HY-145799 5A2-SC8 Chemical 99.89% Unkown
HY-59105 SC-560 Inhibitor 99.79% Unkown
HY-13802 SC-514 Inhibitor 99.97% Unkown
HY-145758 FEN1-IN-SC13 Inhibitor 98.42% Unkown
HY-126681 SC-VC-PAB-MMAE 99.07% Unkown
HY-140698 m-PEG5000-NHS ester 95.0% Unkown
HY-W591424 m-PEG2000-NHS ester Ligand 95.89% Unkown
HY-15614A SC144 hydrochloride 98.98% Unkown
HY-161409 SC912 99.13% Unkown
HY-124876 SynuClean-D Inhibitor 99.89% Unkown
HY-103226 SC-57461A Inhibitor 99.93% Unkown
HY-16012A Domatinostat 99.34% Unkown
HY-P0323A GP(33-41) TFA Inhibitor 99.62% Unkown
HY-18086 TCS PIM-1 1 Inhibitor 98.40% Unkown
HY-108562 SC-51322 Antagonist 98.93% Unkown
HY-Y0079S D-Phenylalanine-d5 99.92% Unkown
HY-W010983 SC-236 99.59% Unkown
HY-19832 SC66 99.65% Unkown
HY-157745 m-PEG40000-NHS ester 98.0% Unkown
HY-144880 SC209 Inhibitor 98.99% Unkown
HY-101955A (2R,6R)-Hydroxynorketamine hydrochloride 99.91% Unkown
HY-164373 SC428 98.0% Unkown
HY-158031 PLK1/BRD4-IN-5 98.80% Unkown
HY-100931 SC-10 Activator 99.59% Unkown
HY-108563A SC 51089 free base Antagonist 98.60% Unkown
HY-131236 EBNA1-IN-SC7 98.37% Unkown
HY-145799A 5A2-SC8 TFA Chemical 98.85% Unkown
HY-155656 Anti-inflammatory agent 49 Inhibitor 99.44% Unkown
HY-203862 Polyquaternium-51 / Unkown
HY-P10827 PIC1 PA Inhibitor 98.37% Unkown
HY-140699 m-PEG10000-NHS ester 98.0% Unkown
HY-W013164 SC-58125 Inhibitor 99.92% Unkown
HY-Y0079S1 D-Phenylalanine-d8 98.28% Unkown
HY-114857 Clofencet 98.62% Unkown
HY-120113 SC-2001 99.37% Unkown
HY-124858 SC99 98.90% Unkown
HY-177069 4A3-SC7 98.55% Unkown
HY-118827 Vedaprofen Inhibitor 98.73% Unkown
HY-138865 BiCAPPA Inhibitor 98.35% Unkown
HY-140700 m-PEG20000-NHS ester 98.0% Unkown
HY-N9319 Fulvotomentoside A 99.76% Unkown
HY-102065 SC-19220 99.86% Unkown
HY-171099 SC-919 Inhibitor 98.68% Unkown
HY-132306 CCF0058981 Inhibitor 98.02% Unkown
HY-148194 SC239 99.97% Unkown
HY-124775 (S)-C33 Inhibitor 99.46% Unkown
HY-126693 SC-VC-PAB-DM1 97.04% Unkown
HY-129982 SC-435 99.14% Unkown
HY-B0561S Spironolactone-d7 99.96% Unkown
HY-47968 SC209 intermediate-1 ≥96.0% Unkown
HY-106395A (Rac)-Telinavir Inhibitor / Unkown
HY-108563 SC 51089 Antagonist 98.64% Unkown
HY-148402 p53 Activator 3 Activator 98.35% Unkown
HY-148404 p53 Activator 5 Activator 98.43% Unkown
HY-148528 SC-VC-PAB-N-Me-L-Ala-Maytansinol 98.66% Unkown
HY-B0455S Lomefloxacin-d5 hydrochloride 99.88% Unkown
HY-B0561S1 Spironolactone-d3 99.87% Unkown
HY-P3326A Targeting the bacterial sliding clamp peptide 46 TFA Inhibitor 99.83% Unkown
HY-W009934 2-Phenyl-2-(2-pyridyl)acetonitrile 99.97% Unkown
HY-W028047 JFD01307SC Inhibitor 98.0% Unkown
HY-U00129 SC57666 Inhibitor 98.94% Unkown
HY-100857 PrPSc-IN-1 / Unkown
HY-B0361S1 Aspartame-d5 / Unkown
HY-105052 SC 34301 / Unkown
HY-105894 SC-42867 Antagonist / Unkown
HY-10828 SC-57461 Inhibitor / Unkown
HY-111251 4SC-207 / Unkown
HY-112740 SC-53228 Antagonist / Unkown
HY-113727 SC-39070 Antagonist / Unkown
HY-114786 SC-44463 Inhibitor / Unkown
HY-115360 IND45193 Inhibitor / Unkown
HY-117896 SC-50605 Antagonist / Unkown
HY-118795 SC-22716 Inhibitor / Unkown
HY-119753 Disobutamide Inhibitor / Unkown
HY-120053 SC-53606 Antagonist / Unkown
HY-120776 SC-51316 Antagonist / Unkown
HY-120794 SC-67655 / Unkown
HY-121598 Actisomide Inducer / Unkown
HY-122134 SC-58272 Inhibitor / Unkown
HY-123014 (Rac)-SC-45694 Agonist / Unkown
HY-123014A SC-45694 lithium / Unkown
HY-123229 Ropizine / Unkown
HY-123864 SC-68448 Antagonist / Unkown
HY-124985 VU6010608 Modulator / Unkown
HY-125494 Droxinavir hydrochloride Inhibitor / Unkown
HY-125494A Droxinavir Inhibitor / Unkown
HY-126667 SC-Val-Cit-PAB / Unkown
HY-129782 SC-55858 / Unkown
HY-139678 SC13 / Unkown
HY-14237 SC-77964 Inhibitor / Unkown
HY-156271 Tubulin polymerization-IN-52 Inhibitor / Unkown
HY-162791 (1s,4s)-C1-Piperidine-C1-cyclohexane-C1 / Unkown
HY-168730 Anticancer agent 259 Modulator / Unkown
HY-172133 HDAC3-IN-6 / Unkown
HY-172887 Kv7.2/Kv7.3 activator-2 Activator / Unkown
HY-172944 GPR40 Activator 3 Activator / Unkown
HY-17474AS Parecoxib-d5 sodium Inhibitor / Unkown
HY-17474S Parecoxib-d3 Inhibitor / Unkown
HY-174808 SC691 Inhibitor / Unkown
HY-17509S Deracoxib-d3 / Unkown
HY-175318S p53 Activator 15 Activator / Unkown
HY-176065 Nav1.2-IN-1 Inhibitor / Unkown
HY-178732 AB-22 Inhibitor / Unkown
HY-181980 SPB07393SC Inhibitor / Unkown
HY-182309 SC83288 Inhibitor / Unkown
HY-184428 PROTAC TSSK1 Degrader-1 Degrader / Unkown
HY-184728 Antifungal agent-169 Inhibitor / Unkown
HY-400056 SC209 intermediate-2 99.60% Unkown
HY-B0561S2 Spironolactone-d3-1 / Unkown
HY-D2996 BOD-NH-SC / Unkown
HY-E70596 endo-α-1,5-Arabinanases, Paenibacillus polymyxa SC2 / Unkown
HY-N12229 Penipurdin A Inhibitor / Unkown
HY-N12871 Floramanoside D Inhibitor / Unkown
HY-N15703 Norisocorydine / Unkown
HY-N16606 2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone Inhibitor / Unkown
HY-N17737 Floramanoside F / Unkown
HY-N19135 SB87-H Inhibitor / Unkown
HY-N19661 1-O-Caffeoyl-3-O-galloyl-β-D-glucopyranose / Unkown
HY-N9229 Myricadenin A Inhibitor / Unkown
HY-P3326 Targeting the bacterial sliding clamp peptide 46 Inhibitor / Unkown
HY-RS12473 SC5D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12514 SCLY Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1130429 4A3-SC10 Inhibitor / Unkown
HY-W717425 SC-60 / Unkown
HY-W777079 Valdecoxib-13C2,15N / Unkown
HY-102065R SC-19220 (Standard) / Unkown
HY-106593 Prorenone Antagonist / Unkown
HY-112333 SC-68376 Inhibitor / Unkown
HY-117717 (Rac)-SC-31391 Activator / Unkown
HY-118827S Vedaprofen-d3 Inhibitor / Unkown
HY-120045A DuP 747 hydrochloride / Unkown
HY-120550 RS 49676 Inhibitor / Unkown
HY-120586 SC-46944 Inhibitor / Unkown
HY-122288 SC 28538 Inhibitor / Unkown
HY-123156 SC-23110 Inhibitor / Unkown
HY-123354 SC 44914 Inhibitor / Unkown
HY-123747 SC-53116 Agonist / Unkown
HY-123747A SC-53116 hydrochloride Agonist / Unkown
HY-137089 Azacosterol dihydrochloride Inhibitor / Unkown
HY-137225 HTS07944 / Unkown
HY-157405 DENV-IN-11 Inhibitor / Unkown
HY-163631 Antibacterial agent 218 Inhibitor / Unkown
HY-164525 SD-7300 Inhibitor / Unkown
HY-165401 SC 19886 Inhibitor / Unkown
HY-168776 (S)-C12-200 / Unkown
HY-170520 Antibiofilm agent-14 Inhibitor / Unkown
HY-172411 GLP-1R agonist 29 Agonist / Unkown
HY-172536 m-PEG30000-NHS ester / Unkown
HY-17474S1 Parecoxib-d5 Inhibitor / Unkown
HY-175697 Glycosyltransferase-IN-2 Inhibitor / Unkown
HY-180145 Furin-IN-3 Inhibitor / Unkown
HY-181494 FAPI-X5 Inhibitor / Unkown
HY-B0361S Aspartame-d3 / Unkown
HY-N12164 Linearmycin B Inhibitor / Unkown
HY-N14006 Louisianin D / Unkown
HY-N14139 Dioxamycin Inhibitor / Unkown
HY-N14632 Louisianin A / Unkown
HY-N14633 Louisianin B / Unkown
HY-N14634 Louisianin C / Unkown
HY-RS19952 Scly Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26454 Scly Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W703540 Deracoxib-d4 / Unkown
HY-P0323 GP(33-41) Inhibitor / Unkown
HY-U00200 Dicirenone Antagonist / Unkown
HY-U00239 SC58451 Inhibitor / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991041 Turmetabart 99.75% Unkown
HY-P99506 Tamrintamab 98.51% Unkown
HY-P990664 Anti-Melanotransferrin/CD228 Antibody 99.33% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SCLY MGD MGI:1355310
Felis catus SCLY VGNC VGNC:80349
Canis familiaris SCLY VGNC VGNC:59093
Rattus norvegicus SCLY RGD RGD:1359514
Macaca mulatta SCLY VGNC VGNC:81563
Bos taurus SCLY VGNC VGNC:55677
Others SCLY NCBI