2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. 4SC-207

4SC-207 is a potent, orally active microtubule inhibitor. 4SC-207 inhibits microtubule growth to inhibit tumor cell proliferation in vitro and in vivo, and promotes a mitotic delay/arrest, followed by apoptosis or aberrant divisions. 4SC-207 inhibits tumor growth in taxane resistant xenograft mouse models. 4SC-207 can be used for cancer research, such as colon adenocarcinoma and other malignancies.

For research use only. We do not sell to patients.

4SC-207

4SC-207 Chemical Structure

CAS No. : 871015-11-1

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4SC-207 Related Antibodies

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Description

4SC-207 is a potent, orally active microtubule inhibitor. 4SC-207 inhibits microtubule growth to inhibit tumor cell proliferation in vitro and in vivo, and promotes a mitotic delay/arrest, followed by apoptosis or aberrant divisions. 4SC-207 inhibits tumor growth in taxane resistant xenograft mouse models. 4SC-207 can be used for cancer research, such as colon adenocarcinoma and other malignancies[1].

In Vitro

4SC-207 (10 nM-100 μM, 24-72 h) reduces cell viability and induces a G2/M arrest only in proliferating RKO cells[1].
4SC-207 (10 nM-100 nM, 9 h) induces, in a dose dependent manner, aberrant divisions, following a prolonged mitosis, or mitotic arrest in HeLa wt cells, and affects all cells at 100 nM[1].
4SC-207 (0-2 μM, 0-20 min) inhibits tubulin polymerization in a dose-dependent manner in an in vitro assay using purified pig-brain tubulin[1].
4SC-207 (50-100 nM) reduces microtubule growth speeds in living HeLa cells[1].
4SC-207 (72 h) exhibits potent anti-proliferative agent active on a broad range of tumor cells with an average GI50 of 11nM, and is active in multi-drug resistant cell lines, such as HCT-15 and ACHN[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4SC-207 Related Antibodies

Cell Viability Assay[1]

Cell Line: RKO cells
Concentration: 10 nM-100 μM
Incubation Time: 72 h
Result: Reduced the percentage of viable cells from 100% to 20% when added at or above a concentration of 100 nM.

Cell Cycle Analysis[1]

Cell Line: RKO cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Showed a strong increase in the percentage of cells in G2/M phase (52% compared to 24% of DMSO-treated cells).
Decreased the amount of cells in G1 and S phases (respectively 14% and 10% compared to 53% and 20% in control cells).
In Vivo

4SC-207 (60 and 120 mg/kg, i.g., 3 times weekly for 3 weeks) shows anti-proliferative activity also in the context of a tumor resistant to Taxol (HY-B0015) treatment in an HCT-15 xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID mice subcutaneously implanted with HCT-15 colon cancer cells[1]
Dosage: 60 and 120 mg/kg
Administration: i.g., 3 times weekly for 3 weeks
Result: Resulted in a reduction in tumor growth, in a dose dependent manner, without evidence of toxicity based on body weight measurements.
Resulted in significant tumor reduction at day 12, day 14, and day 19 at 120 mg/kg.
Molecular Weight

382.44

Formula

C19H18N4O3S
CAS No.
SMILES

O=C(N1CCC(C(C#N)=C(NC(/C=C/C2=CC=CN=C2)=O)S3)=C3C1)OCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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4SC-207 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4SC-207871015-11-1Microtubule/TubulinApoptosisHCT-15ACHNmicrotubuletaxane resistantcolon adenocarcinomamalignanciesInhibitorinhibitorinhibit

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