SC209 intermediate-2

Cat. No.: HY-400056: FAQs
Data Sheet SDS COA Handling Instructions

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SC209 intermediate-2 (Compound A9) is an intermediate of the ADC cytotoxin SC209 (HY-144880). SC209 intermediate-2 is an ADC Linker.

For research use only. We do not sell to patients.

SC209 intermediate-2 Chemical Structure

CAS No. : 1977557-83-7

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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

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Biological Activity
Purity & Documentation
References
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Description

SC209 intermediate-2 (Compound A9) is an intermediate of the ADC cytotoxin SC209 (HY-144880). SC209 intermediate-2 is an ADC Linker^[1].

Molecular Weight

616.83

Formula

C₃₄H₅₆N₄O₆

CAS No.

1977557-83-7

Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C1=CC(N)=CC=C1)[C@H](N(C)C(OC(C)(C)C)=O)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(OCC)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (324.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6212 mL	8.1060 mL	16.2119 mL
5 mM	0.3242 mL	1.6212 mL	3.2424 mL
10 mM	0.1621 mL	0.8106 mL	1.6212 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (8.11 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (270 KB) SDS (0 KB)

COA (248 KB) HNMR (232 KB) LCMS (109 KB)

Handling Instructions (2659 KB)

References

[1]. Toni Kline, et al. Hemiasterlin derivatives for conjugation and therapy. Patent. WO2016123582.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6212 mL	8.1060 mL	16.2119 mL	40.5298 mL
	5 mM	0.3242 mL	1.6212 mL	3.2424 mL	8.1060 mL
	10 mM	0.1621 mL	0.8106 mL	1.6212 mL	4.0530 mL
	15 mM	0.1081 mL	0.5404 mL	1.0808 mL	2.7020 mL
	20 mM	0.0811 mL	0.4053 mL	0.8106 mL	2.0265 mL
	25 mM	0.0648 mL	0.3242 mL	0.6485 mL	1.6212 mL
	30 mM	0.0540 mL	0.2702 mL	0.5404 mL	1.3510 mL
	40 mM	0.0405 mL	0.2026 mL	0.4053 mL	1.0132 mL
	50 mM	0.0324 mL	0.1621 mL	0.3242 mL	0.8106 mL
	60 mM	0.0270 mL	0.1351 mL	0.2702 mL	0.6755 mL
	80 mM	0.0203 mL	0.1013 mL	0.2026 mL	0.5066 mL
	100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.4053 mL