Turmetabart  (Synonyms: Anti-SEZ6 Antibody (SC17); ABBV-011 antibody; ABBV-706 antibody)

Turmetabart (Anti-SEZ6 Antibody (SC17)) is a humanized anti-SEZ6 IgG1 monoclonal antibody. Anti-SEZ6 Antibody (SC17) can be used to synthesize antibody-drug conjugates (ADC) product, ABBV-011. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

ADC antibodies act as the navigation system of ADC drugs and are primarily responsible for delivering payloads to target cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

124925  [NCBI]

Q53EL9

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

144.6 kDa

2650574-80-2

Liquid

Colorless to light yellow

[Turmetabart]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  IgG1-kappa

• 
  Immobilized HuSEZ6-ECD(20-925)-His can bind Anti-SEZ6 Antibody (SC17). The EC₅₀ for this effect is 12.34 ng/mL.
• 
  Flow Cytometry analysis of Hela cells labelling SEZ6 (red) with Turmetabart (HY-P991041). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

• [1]. Wolf R Wiedemeyer, et al. ABBV-011, A Novel, Calicheamicin-Based Antibody-Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors. Mol Cancer Ther. 2022 Jun 1;21(6):986-998.  [Content Brief]

  [2]. WHO Drug Information-Volume 39, No. 2.