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Cat. No.: HY-165401

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SC 19886

SC 19886 is an inhibitor of Aldosterone (HY-113313) synthesis. SC 19886 blocks Aldosterone-induced DNA-dependent RNA synthesis. SC 19886 can be used in studies related to primary aldosteronism.

For research use only. We do not sell to patients.

CAS No.: 22785-18-8
Formula: C₁₉H₂₆O₂
Molecular Weight:286.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SC 19886 Chemical Structure

CAS No.: 22785-18-8

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Biological Activity
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Chemical Information
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Biological Activity

Description

SC 19886 is an inhibitor of Aldosterone (HY-113313) synthesis. SC 19886 blocks Aldosterone-induced DNA-dependent RNA synthesis. SC 19886 can be used in studies related to primary aldosteronism^[1]^[2].

All DNA/RNA Synthesis Isoforms :

In Vitro

SC 19886 (infused at 0.1 mM) completely inhibits spontaneous aldosterone production in perfused Rana ridibunda frog adrenal interrenal fragments, and this irreversible effect persists for at least 7 h, while it also completely blocks the stimulatory effects of ACTH and angiotensin II on aldosterone biosynthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 22785-18-8
Molecular Weight 286.41
Formula C₁₉H₂₆O₂
SMILES

C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@@]([C@H](C(CC4)=O)C)([H])C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Netchitailo P, et al. Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro. Biochemical pharmacology. 1985 Jan 15;34(2):189-94. [Content Brief]

[2]. Porter GA, et al. The effect of a new anti-aldosterone agent SC19886 on aldosterone-stimulated transepithelial sodium transport. J Steroid Biochem. 1972 Feb;3(2):201-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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Purity & Documentation
References

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SC 19886

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SC 19886 Related Classifications

HY-165401 Related Classifications