2. Neuronal Signaling
  3. Prion Protein
  4. IND45193

IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.

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IND45193

IND45193 Chemical Structure

CAS No. : 10024-04-1

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Description

IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.

Cellular Effect
Cell Line Type Value Description References
HT-22 EC50
2.8 μM
Compound: 60
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
[PMID: 24602904]
HT-22 EC50
> 25 μM
Compound: 60
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
[PMID: 24602904]
N2a #58 F3 EC50
2.04 μM
Compound: 10
Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method
Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method
[PMID: 21531054]
ScN2a EC50
0.14 μM
Compound: 10
Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method
Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method
[PMID: 21531054]
Molecular Weight

352.86

Formula

C20H21ClN4
CAS No.
SMILES

ClC1=CC2=NC=CC(NC3=CC=C(N4CCN(CC4)C)C=C3)=C2C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IND45193 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IND4519310024-04-1IND 45193IND-45193Prion ProteinInhibitorinhibitorinhibit

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