IND45193
IND45193 is a compound used to inhibit prion disease, with activity in reducing PrP(Sc) levels. In cells infected with prions, IND45193 can reduce PrP(Sc) levels, and its activity was determined through screening of multiple cell types and concentration-effect relationship studies.
For research use only. We do not sell to patients.
- CAS No.: 10024-04-1
- Formula: C20H21ClN4
- Molecular Weight:352.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-22 | EC50 |
>25 μM
Compound: 60
|
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
Cytotoxicity against mouse HT22 cells after 24 hrs by MTT assay
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[PMID: 24602904] |
| HT-22 | EC50 |
2.8 μM
Compound: 60
|
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
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[PMID: 24602904] |
| N2a #58 F3 | EC50 |
2.04 μM
Compound: 10
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Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method
Antiprion activity against human prion protein Fukuoka-1 infected mouse F3 cells assessed as reduction of PrPSc level by Western blot method
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[PMID: 21531054] |
| ScN2a | EC50 |
0.14 μM
Compound: 10
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Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method
Antiprion activity against mouse prion protein RML infected mouse ScN2a cells assessed as reduction of PrPSc level by Western blot method
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[PMID: 21531054] |
Chemical Information
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CAS No. 10024-04-1
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Molecular Weight 352.86
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Formula C20H21ClN4
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SMILES
ClC1=CC2=NC=CC(NC3=CC=C(N4CCN(CC4)C)C=C3)=C2C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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