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Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His)

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Based on 1 publication(s) in Google Scholar

Semaphorin-3A/SEMA3A Protein guides growth cones and is implicated in sensory projection patterning, selectively repelling axons that terminate dorsally.It contributes to olfactory system development and neuronal control of puberty.SEMA3A interacts with PXND1, although the exact nature of this interaction is unspecified.Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Semaphorin-3A/SEMA3A protein, expressed by HEK293 , with N-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His) Product Image
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  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

Semaphorin-3A/SEMA3A Protein guides growth cones and is implicated in sensory projection patterning, selectively repelling axons that terminate dorsally.It contributes to olfactory system development and neuronal control of puberty.SEMA3A interacts with PXND1, although the exact nature of this interaction is unspecified.Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Semaphorin-3A/SEMA3A protein, expressed by HEK293 , with N-His labeled tag.

Background

The Semaphorin-3A/SEMA3A protein plays a crucial role in guiding growth cones. It is believed to participate in patterning sensory projections by selectively repelling axons that typically terminate dorsally. SEMA3A is also involved in the development of the olfactory system and contributes to neuronal control of puberty. Additionally, it interacts with PXND1, although the exact nature of this interaction is not specified.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag N-8*His
  • Accession

    O08665 (N21-V772)

  • Gene ID
    20346  [NCBI]
  • Molecular Construction
    • N-term
    • 8*His
    • SEMA3A (N21-V772)
      Accession # O08665
    • C-term
  • Protein Length

    Full Length of Mature Protein

  • Synonyms

    SEMA3A; Sema III; Prev. SEMAD; Semaphorin D; Hsema-I; Semaphorin L; Coll-1; Collapsin 1; SEMA1; Hsema-III; SemD; SEMAIII; Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3A; COLL1; Semaphorin III; SEMAL; Semaphorin-3A;

  • AA Sequence

    NYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV

  • Predicted Molecular Mass

    86.6 kDa

  • Molecular Weight

    Approximately 65-70 kDa, based on SDS-PAGE under reducing conditions.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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