Sema3a - sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A Gene

Also Known as SemD; SEMA1; Semad; coll-1; Hsema-I

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20346

Summary

Enables chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including nervous system development; positive regulation of male gonad development; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including dichotomous subdivision of terminal units involved in salivary gland branching; generation of neurons; and negative regulation of epithelial cell migration. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A). [provided by Alliance of Genome Resources, Apr 2022]

Sema3a Products (3)

mRNA Protein Name
NM_001243072.1 NP_001230001.1 semaphorin-3A precursor
NM_001243073.1 NP_001230002.1 semaphorin-3A precursor
NM_009152.4 NP_033178.2 semaphorin-3A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemorepellent activity IDA
IDA: Inferred from direct assay
11683995 MGI
enables neuropilin binding IPI
IPI: Inferred from physical interaction
15239958 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23104057 MGI
enables semaphorin receptor binding IPI
IPI: Inferred from physical interaction
15239958 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of axon extension IDA
IDA: Inferred from direct assay
12852851 MGI
acts upstream of axon extension IGI
IGI: Inferred from genetic interaction
12852851 MGI
acts upstream of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
7748561 MGI
acts upstream of axon extension involved in axon guidance IGI
IGI: Inferred from genetic interaction
11683995 MGI
involved in axon extension involved in axon guidance IMP
IMP: Inferred from mutant phenotype
22790009 MGI
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
12435358 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15604101 MGI
acts upstream of or within axonal fasciculation IMP
IMP: Inferred from mutant phenotype
17428830 MGI
involved in axonogenesis involved in innervation IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in basal dendrite arborization IGI
IGI: Inferred from genetic interaction
22683681 MGI
involved in branchiomotor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
18804103 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
12372285 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IDA
IDA: Inferred from direct assay
17626059 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IGI
IGI: Inferred from genetic interaction
17626059 MGI
acts upstream of epithelial cell migration IDA
IDA: Inferred from direct assay
17626059 MGI
involved in facial nerve structural organization IMP
IMP: Inferred from mutant phenotype
18804103 MGI
involved in facioacoustic ganglion development IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IMP
IMP: Inferred from mutant phenotype
21059704 MGI
involved in maintenance of synapse structure IDA
IDA: Inferred from direct assay
24831527 MGI
involved in maintenance of synapse structure IMP
IMP: Inferred from mutant phenotype
24831527 MGI
involved in motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
18804103 MGI
acts upstream of or within negative chemotaxis IGI
IGI: Inferred from genetic interaction
11683995 MGI
acts upstream of or within negative regulation of axon extension IDA
IDA: Inferred from direct assay
12852851 MGI
acts upstream of or within negative regulation of axon extension IGI
IGI: Inferred from genetic interaction
12852851 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
7748561 MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance IGI
IGI: Inferred from genetic interaction
11683995 MGI
acts upstream of or within negative regulation of epithelial cell migration IDA
IDA: Inferred from direct assay
17626059 MGI
involved in nerve development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
acts upstream of or within nervous system development IGI
IGI: Inferred from genetic interaction
12591607 MGI
involved in neural crest cell migration involved in autonomic nervous system development IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in neural crest cell migration involved in sympathetic nervous system development IMP
IMP: Inferred from mutant phenotype
19325129 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
21059704 MGI
involved in positive regulation of male gonad development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in positive regulation of neuron migration IGI
IGI: Inferred from genetic interaction
21828096 MGI
involved in regulation of axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
15155748 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
17417650 MGI
acts upstream of or within semaphorin-plexin signaling pathway IGI
IGI: Inferred from genetic interaction
12591607 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
18804103 MGI
involved in sympathetic ganglion development IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sympathetic neuron projection extension IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in sympathetic neuron projection guidance IMP
IMP: Inferred from mutant phenotype
22790009 MGI
involved in synaptic target recognition IDA
IDA: Inferred from direct assay
22179111 MGI
involved in synaptic target recognition IMP
IMP: Inferred from mutant phenotype
22179111 MGI
involved in trigeminal ganglion development IMP
IMP: Inferred from mutant phenotype
18356247 MGI
involved in trigeminal nerve structural organization IMP
IMP: Inferred from mutant phenotype
18804103 MGI
involved in ventral trunk neural crest cell migration IMP
IMP: Inferred from mutant phenotype
19386662 MGI
Cellular Component GO Annotation Evidence References Source
is active in cerebellar climbing fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
24831527 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
24831527 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22179111 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22179111 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-3A

  • collapsin-1

  • sema D

  • sema III

  • semaphorin III

  • semaphorin-D

Sema3a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sema3a O08665 Nrp1 Mus musculus P97333
SPR
23104057
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Sema3a Proteins

Cat. No. Product Name Accession Purity
HY-P74566 Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, Fc) O08665 (K26-F546) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78350 Semaphorin-3A/SEMA3A Protein, Mouse (HEK293, His) O08665 (N21-V772) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103511 TCS1105 99.44% Unkown
HY-RS12650 SEMA3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17258 Sema3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23712 Sema3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992302 Anti-SEMA3A Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema3a NCBI NCBI:10371