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Serpin A7 Protein, Human (HEK293, His)

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Serpin A7, or thyroxine-binding globulin (TBG), acts as a glycoprotein carrier for thyroid hormones, specifically binding and transporting thyroxine (T4) and triiodothyronine (T3). TBG regulates the availability and distribution of thyroid hormones critical for physiological processes like metabolism and growth. Mutations in the SERPINA7 gene can affect TBG function, influencing thyroid hormone levels. Serpin A7 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A7 protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

Serpin A7, or thyroxine-binding globulin (TBG), acts as a glycoprotein carrier for thyroid hormones, specifically binding and transporting thyroxine (T4) and triiodothyronine (T3). TBG regulates the availability and distribution of thyroid hormones critical for physiological processes like metabolism and growth. Mutations in the SERPINA7 gene can affect TBG function, influencing thyroid hormone levels. Serpin A7 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A7 protein, expressed by HEK293 , with C-6*His labeled tag.

Background

Serpin A7, also known as thyroxine-binding globulin (TBG), is a glycoprotein that primarily functions as a carrier for thyroid hormones in the bloodstream. It specifically binds to and transports thyroxine (T4) and triiodothyronine (T3). TBG plays a crucial role in regulating the availability and distribution of thyroid hormones, which are essential for various physiological processes, including metabolism and growth. Mutations in the SERPINA7 gene can lead to alterations in TBG function, impacting thyroid hormone levels.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-6*His
  • Accession

    P05543 (A21-A415)

  • Gene ID
    6906  [NCBI]
  • Molecular Construction
    • N-term
    • Serpin A7 (A21-A415)
      Accession # P05543
    • 6*His
    • C-term
  • Protein Length

    Full Length of Mature Protein

  • Synonyms

    SERPINA7; Thyroxin-Binding Globulin; Prev. TBG; Serpin A7; Thyroxine-Binding Globulin; Alpha-1 Antiproteinase, Antitrypsin; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7; Mutant Serpin Family A Member 7

  • AA Sequence

    ASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA

  • Predicted Molecular Mass

    49.9 kDa

  • Molecular Weight

    Approximately 55-65 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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