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  2. Enzymes & Regulators
  3. Protease Inhibitors
  4. Serpin (Protease Inhibitor)
  5. Thyroxine-Binding Globulin
  6. Serpin A7 Protein, Human (HEK293, His)

Serpin A7 Protein, Human (HEK293, His)

Cat. No.: HY-P71079
COA Handling Instructions

Serpin A7, or thyroxine-binding globulin (TBG), acts as a glycoprotein carrier for thyroid hormones, specifically binding and transporting thyroxine (T4) and triiodothyronine (T3). TBG regulates the availability and distribution of thyroid hormones critical for physiological processes like metabolism and growth. Mutations in the SERPINA7 gene can affect TBG function, influencing thyroid hormone levels. Serpin A7 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A7 Protein, Human (HEK293, His) is 395 a.a., with molecular weight of 55-65 kDa.

For research use only. We do not sell to patients.

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Description

Serpin A7, or thyroxine-binding globulin (TBG), acts as a glycoprotein carrier for thyroid hormones, specifically binding and transporting thyroxine (T4) and triiodothyronine (T3). TBG regulates the availability and distribution of thyroid hormones critical for physiological processes like metabolism and growth. Mutations in the SERPINA7 gene can affect TBG function, influencing thyroid hormone levels. Serpin A7 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A7 Protein, Human (HEK293, His) is 395 a.a., with molecular weight of 55-65 kDa.

Background

Serpin A7, also known as thyroxine-binding globulin (TBG), is a glycoprotein that primarily functions as a carrier for thyroid hormones in the bloodstream. It specifically binds to and transports thyroxine (T4) and triiodothyronine (T3). TBG plays a crucial role in regulating the availability and distribution of thyroid hormones, which are essential for various physiological processes, including metabolism and growth. Mutations in the SERPINA7 gene can lead to alterations in TBG function, impacting thyroid hormone levels.

Species

Human

Source

HEK293

Tag

C-6*His

Accession

P05543 (A21-A415)

Gene ID
Molecular Construction
N-term
Serpin A7 (A21-A415)
Accession # P05543
6*His
C-term
Synonyms
Thyroxine-Binding Globulin; Serpin A7; T4-Binding Globulin; SERPINA7; TBG
AA Sequence

ASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA

Molecular Weight

55-65 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Serpin A7 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Serpin A7 Protein, Human (HEK293, His)
Cat. No.:
HY-P71079
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