SERPINA7 - serpin family A member 7 Gene

Homo sapiens

Also known as TBG; TBGQTL

Gene ID: 6906 | Gene type: protein coding

About SERPINA7

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,032,435-106,038,727 (from NCBI)

This gene has 3 transcripts (splice variants), 92 orthologues, 36 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 70.5).

Summary

There are three proteins including Thyroxine-Binding Globulin (TBG), transthyretin and albumin responsible for carrying the thyroid Hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

SERPINA7 Products(1)

mRNA	Protein	Name
NM_000354.6	NP_000345.2	thyroxine-binding globulin precursor

SERPINA7 Protein Structure

Serpin

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

thyroxine-binding globulin

T4-binding globulin

Recombinant SERPINA7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71079	Serpin A7 Protein, Human (HEK293, His)	P05543 (A21-A415)	≥95%

Related Diseases

Diseases

Alias

Thyroxine-Binding Globulin Quantitative Trait Locus

TBGQTL

Thyroxine-Binding Globulin Qtl

Hyperthyroxinemia

Euthyroid Sick Syndrome

Euthyroid Sick Syndromes	Sick-Euthyroid Syndrome
Ess - [Euthyroid Sick Syndrome]	Low-T3 Syndrome
Ntis - [Non-Thyroidal Illness Syndrome]	Tscitus - [Thyroid Allostasis In Critical Illness, Tumours, Uraemia And Starvation]

Hyperthyroidism

Overactive Thyroid

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Goiter

Goitre

Thyroid Hormone Resistance, Generalized, Autosomal Dominant

Thyroid Hormone Resistance Syndrome	Thyroid Hormone Resistance
GRTHD	Gthr
Thyroid Hormone Unresponsiveness	Generalized Thyroid Hormone Resistance
Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Thyroid Hormones	Hyperthyroxinemia, Familial Euthyroid, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones
Refetoff Syndrome	Thyroid Hormone Responsiveness Defect
Familial Euthyroid Hyperthyroxinemia, Secondary To Pituitary And Peripheral Resistance To Thyroid Hormones	Thyroid Hormone Resistance, Generalized, Autosomal Recessive

Placental Abruption

Abruptio Placentae	Abruptio Placenta
Abortion, Threatened	Threatened Miscarriage
Haemorrhage Specified As Due To Threatened Abortion	Spontaneous Threatened Abortion

Graves' Disease

Graves Disease	Exophthalmic Goiter
Basedow'S Disease	Grave'S Disease
Basedow Disease	Toxic Diffuse Goiter
Graves' Hyperthyroidism	Parry Disease
Autoimmune Hyperthyroidism	Toxic Multinodular Goiter

Congenital Disorder Of Glycosylation, Type Ia

CDG1A	Cdg Ia
Phosphomannomutase 2 Deficiency	Jaeken Syndrome
Pmm2-Congenital Disorder Of Glycosylation	Congenital Disorder Of Glycosylation Type Ia
Cdgia	Congenital Disorder Of Glycosylation Ia
Congenital Disorder Of Glycosylation 1a	Carbohydrate-Deficient Glycoprotein Syndrome Type Ia
Cdgs1a	Pmm2-Cdg
Cdg-Ia	Congenital Disorder Of Glycosylation Type 1a
Carbohydrate-Deficient Glycoprotein Syndrome, Type Ia, Formerly	Pmm Deficiency
Cdg Syndrome Type Ia	Carbohydrate Deficient Glycoprotein Syndrome Type Ia
Cdg Syndrome Type 1a	Jaeken'S Syndrome
Pmm2 Deficiency	Glycosylation, Congenital Disorder Of, Type Ia

Thyroid Crisis

Thyrotoxic Crisis	Thyroid Storm
Thyrotoxic Storm

Turner Syndrome

Monosomy X	Gonadal Dysgenesis Turner Type
Ullrich-Turner Syndrome	Bonnevie-Ullrich Syndrome
Karyotype 45, X	Genital Dwarfism, Turner Type
Gonadal Dysgenesis	45,X
Turner'S Syndrome	Gonadal Dysgenesis - Turner
Monosomy X Syndrome	Xo Syndrome
Genital Dwarfism	45, X Syndrome
Bonnevie-Ulrich Syndrome	Chromosome X Monosomy X
Schereshevkii Turner Syndrome	Turner Varny Syndrome
Ts	45,X Syndrome
45,X/46,Xx Syndrome	Turners Syndrome
Gonadal Dysgenesis, 45,X	X0 Syndrome

Graves Disease 1

Thyrotoxicosis	Graves Disease, Susceptibility To, 1
GRD1	Grd
Hyperthyroidism, Autoimmune	Hyperthyroidism
Hyperactive Thyroid Gland	Overactive Thyroid
Toxic Diffuse Goitre	Toxic Primary Thyroid Hyperplasia
Stokes Disease	Thyrotoxicosis With Goitre
Thyrotoxicosis Struma	Graves Disease
Goitre With Hyperthyroidism	Basedow Disease
Exophthalmic Goitre	Exophthalmic Struma
Flajani Disease	Graves Disease With Exophthalmos
Hyperthyroid Goitre	Hyperthyroidism Struma
Thyroid Exophthalmos	Malignant Exophthalmos
Parry Disease	Toxic Diffuse Goitre With Exophthalmos
Toxic Goitre	Toxic Goitre Nos
Thyrotoxicosis Due To Uninodular Goitre	Toxic Thyroid Nodule
Toxic Uninodular Goitre	Uninodular Toxic Struma
Uninodular Toxic Struma With Hyperthyroidism	Thyrotoxicosis Due To Single Thyroid Nodule
Toxic Uninodular Goitre With Hyperthyroidism	Hyperthyroidism With Thyroid Nodule
Thyrotoxicosis With Toxic Uninodular Goitre	Uninodular Goitre In Hyperthyroidism
Uninodular Goitre In Thyrotoxicosis	Toxic Multinodular Goitre
Multinodular Goitre With Thyrotoxicosis	Thyrotoxicosis Nodular Goitre
Nodular Goitre With Thyrotoxicosis	Adenomatous Goitre With Hyperthyroidism
Multinodular Goitre With Hyperthyroidism	Nodular Goitre With Hyperthyroidism
Nodular Struma With Hyperthyroidism	Plummer Disease
Thyrotoxicosis Adenomatous Goitre	Thyrotoxicosis Adenomatous Struma
Toxic Adenomatous Goitre	Toxic Adenomatous Struma
Toxic Nodular Goitre Nos	Toxic Struma Nodosa
Toxic Nodular Struma

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Endemic Goiter

Iodine-Deficiency-Related Endemic Goitre	Simple Goitre
Goiter, Endemic	Euthyroid Goiter

Thyroiditis

Inflammation Of Thyroid

Thyroiditis Nos

Acute Thyroiditis

Infectious Thyroiditis

Corticosteroid-Binding Globulin Deficiency

CBG DEFICIENCY

Transcortin Deficiency

Polyneuropathy

Polyneuropathies

Thyroid Gland Disease

Abnormality Of The Thyroid Gland

Thyroid Diseases

Thyroid Hormone Resistance, Selective Pituitary

PRTH	Selective Pituitary Thyroid Hormone Resistance
Selective Pituitary Resistance To Thyroid Hormone	Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion
Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion	Pituitary Resistance To Thyroid Hormone

Hashimoto Thyroiditis

Autoimmune Thyroiditis	Hashimoto Struma
Hashimoto'S Thyroiditis	Chronic Lymphocytic Thyroiditis
Lymphocytic Thyroiditis	Hashimoto Disease
Ht	Hashimoto'S Disease
Hashimoto'S Syndrome	Hypothyroidism, Autoimmune
Autoimmune Chronic Lymphocytic Thyroiditis	Chronic Lymphocytic Thyroiditides
Hashimoto Syndrome	Hashimotos Thyroiditis
Hashimoto Thyroiditis, Susceptibility To	Thyroiditis, Autoimmune
Lymphomatous Thyroiditis	Lymphoid Thyroiditis
Chronic Lymphadenoid Thyroiditis	Autoimmune Lymphocytic Chronic Thyroiditis
Goitre Lymphomatosa	Hashitoxicosis
Hashimoto Hypothyroidism	Lymphadenoid Goitre
Struma Lymphomatosa	Hyperthyroidism With Hashimoto Disease
Hashimoto Thyrotoxicosis	Thyrotoxicosis Due To Hashimoto Thyroiditis
Struma Lymphomatosis	Lymphadenoid Struma

Plummer'S Disease

Toxic Nodular Goiter	Plummer Disease
Goiter Toxic Nodular

Subacute Thyroiditis

Giant-Cell Thyroiditis	Granulomatous Thyroiditis
Subacute Granulomatous Thyroiditis	De Quervain'S Thyroiditis
Thyroiditis Subacute	Thyroiditis, Subacute
Pseudogranulomatous Thyroiditis	De Quervain Thyroiditis
Nonsuppurative Subacute Thyroiditis	Pseudotuberculous Thyroiditis
Nonsuppurative Thyroiditis Nos

Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon

Wild-Type Amyloidosis

Senile Systemic Amyloidosis	Attrwt Amyloidosis
Age Related Amyloidosis	Old Age Amyloidosis
Wild-Type Attr Amyloidosis	Wild-Type Transthyretin Cardiac Amyloidosis
Wild Type Attr Amyloidosis	Attrwt-Related Amyloidosis
Wild Type Attr-Related Amyloidosis

Nontoxic Goiter

Goiter, Non-Toxic	Goitre, Non-Toxic
Nodule-Thyroid, Non Tox	Non-Toxic Goitre
Non-Toxic Simple Goitre	Goitre Nos
Goitre Struma	Enlarged Thyroid Gland
Thyromegaly	Thyroid Hypertrophy
Thyroid Gland Hypertrophy	Thyroid Hyperplasia
Thyroid Gland Hyperplasia	Swelling Of Thyroid Gland
Substernal Thyroid Mass	Substernal Goitre
Substernal Thyroid	Retrosternal Thyroid Struma
Sporadic Nodular Struma	Struma Of Thyroid
Retrosternal Goitre	Plunging Goitre
Nontoxic Nodular Goitre	Nodular Struma
Form Of Goitre	Hyperplastic Goitre
Hypertrophic Thyroid	Intrathoracic Goitre
Nodular Goitre

Myxedema

Allan-Herndon-Dudley Syndrome

AHDS	Allan-Herndon Syndrome
Monocarboxylate Transporter 8 Deficiency	MCT8 DEFICIENCY
Mental Retardation, X-Linked, With Hypotonia	Triiodothyronine Resistance
T3 Resistance	Mental Retardation And Muscular Atrophy
Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency	Intellectual Disability And Muscular Atrophy
Monocarboxylate Transporter-8 Deficiency	T3 Resisitence
Triiodothyronine Resistence	X-Linked Intellectual Disability With Hypotonia
Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency	Monocarboxylate Transporter 8 Deficiency
X-Linked Intellectual Disability-Hypotonia Syndrome

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Estrogen Excess

Hyperestrogenism

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12703	SERPINA7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SERPINA7	MGD	MGI:3041197
Canis familiaris	SERPINA7	VGNC	VGNC:46026
Rattus norvegicus	SERPINA7	RGD	RGD:619833
Bos taurus	SERPINA7	VGNC	VGNC:34469
Felis catus	SERPINA7	VGNC	VGNC:65024
Macaca mulatta	SERPINA7	VGNC	VGNC:77221
Others	SERPINA7	NCBI