SLAMF2/CD48 Protein, Mouse (HEK293, Fc)

CD48 (SLAMF2) is a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells.
CD48 does not have a transmembrane domain and is held at the cell surface by a Glycosylphosphatidylinositol (GPI) anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor, while CD48 interacts with cell surface receptors including 2B4/CD244 or CD2 via its N-terminal immunoglobulin domain to regulate immune cell function and activation.
CD48 participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex, in turn, promotes LCK phosphorylation and subsequent activation.
CD48 also induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244, initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells ^[1][2][3].